Biocompatibility Study of Electrospun Nanocomposite Membranes Based on Chitosan/Polyvinyl Alcohol/Oxidized Carbon Nano-Onions
| العنوان: | Biocompatibility Study of Electrospun Nanocomposite Membranes Based on Chitosan/Polyvinyl Alcohol/Oxidized Carbon Nano-Onions |
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| المؤلفون: | Manuel N. Chaur, José Herminsul Mina Hernandez, Carlos Humberto Valencia Llano, Jorge Iván Castro, Carlos David Grande-Tovar, Mayra Eliana Valencia Zapata |
| المصدر: | Molecules, Vol 26, Iss 4753, p 4753 (2021) Molecules Volume 26 Issue 16 |
| بيانات النشر: | MDPI AG, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | biomedical applications, Thermogravimetric analysis, Materials science, subdermal implantation, Biocompatibility, Pharmaceutical Science, Organic chemistry, Polyvinyl alcohol, Article, Analytical Chemistry, Nanomaterials, Nanocomposites, Chitosan, chemistry.chemical_compound, QD241-441, Electricity, Drug Discovery, Materials Testing, Animals, Physical and Theoretical Chemistry, electrospinning, nanofibrous, Nanocomposite, Membranes, Artificial, Electrospinning, Carbon, Rats, polyvinyl alcohol, chemistry, Chemical engineering, Chemistry (miscellaneous), Nanofiber, tissue engineering, Molecular Medicine, Oxidation-Reduction |
| الوصف: | In recent decades, the number of patients requiring biocompatible and resistant implants that differ from conventional alternatives dramatically increased. Among the most promising are the nanocomposites of biopolymers and nanomaterials, which pretend to combine the biocompatibility of biopolymers with the resistance of nanomaterials. However, few studies have focused on the in vivo study of the biocompatibility of these materials. The electrospinning process is a technique that produces continuous fibers through the action of an electric field imposed on a polymer solution. However, to date, there are no reports of chitosan (CS) and polyvinyl alcohol (PVA) electrospinning with carbon nano-onions (CNO) for in vivo implantations, which could generate a resistant and biocompatible material. In this work, we describe the synthesis by the electrospinning method of four different nanofibrous membranes of chitosan (CS)/(PVA)/oxidized carbon nano-onions (ox-CNO) and the subdermal implantations after 90 days in Wistar rats. The results of the morphology studies demonstrated that the electrospun nanofibers were continuous with narrow diameters (between 102.1 nm ± 12.9 nm and 147.8 nm ± 29.4 nm). The CS amount added was critical for the diameters used and the successful electrospinning procedure, while the ox-CNO amount did not affect the process. The crystallinity index was increased with the ox-CNO introduction (from 0.85% to 12.5%), demonstrating the reinforcing effect of the nanomaterial. Thermal degradation analysis also exhibited reinforcement effects according to the DSC and TGA analysis, with the higher ox-CNO content. The biocompatibility of the nanofibers was comparable with the porcine collagen, as evidenced by the subdermal implantations in biological models. In summary, all the nanofibers were reabsorbed without a severe immune response, indicating the usefulness of the electrospun nanocomposites in biomedical applications. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1420-3049 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90c92c6a48ebf3be753623c85e22efa1 https://www.mdpi.com/1420-3049/26/16/4753 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....90c92c6a48ebf3be753623c85e22efa1 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14203049 |
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