The levels and distribution of synthetic musks (ADBI, AHMI, ATII, HHCB, AHTN, MX and MK) were investigated in farmland soils from the Three Northeast Provinces of China. The total concentrations of SMs ranged from 2.40 ng/g to 12.2 ng/g (dry weight). HHCB and AHTN were the main pollutants that were detected in all samples, accounting for 99.35% of the total SMs. The hazard quotients were 0.0700 and 0.102 for AHTN and HHCB, respectively. Although the results indicate there is no serious environmental impact, the detection frequency of SMs in the farmland soil is high, which demonstrated that SMs are widely used in the Three Northeast Provinces of China. Therefore, more attention should be given to synthetic musks during environment monitoring and risk assessments for their bioaccumulation, lipophilicity and persistence.