Normal Reference Values and z Scores of the Pulmonary Artery Acceleration Time in Children and Its Importance for the Assessment of Pulmonary Hypertension
| العنوان: | Normal Reference Values and z Scores of the Pulmonary Artery Acceleration Time in Children and Its Importance for the Assessment of Pulmonary Hypertension |
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| المؤلفون: | Marlene Grillitsch, Andreas Gamillscheg, Ante Burmas, Gerhard Cvirn, Gernot Grangl, Martin Koestenberger, Alexander Avian, Georg Hansmann |
| المصدر: | Circulation: Cardiovascular Imaging. 10 |
| بيانات النشر: | Ovid Technologies (Wolters Kluwer Health), 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Time Factors, Adolescent, Hypertension, Pulmonary, Acceleration, Youden's J statistic, Pulmonary Artery, 030204 cardiovascular system & hematology, 03 medical and health sciences, 0302 clinical medicine, Heart Rate, Predictive Value of Tests, Reference Values, medicine.artery, Internal medicine, Heart rate, medicine, Humans, Arterial Pressure, Radiology, Nuclear Medicine and imaging, Prospective Studies, 030212 general & internal medicine, Child, Echocardiography, Doppler, Pulsed, Body surface area, business.industry, Infant, Newborn, Area under the curve, Infant, medicine.disease, Pulmonary hypertension, Confidence interval, Surgery, medicine.anatomical_structure, ROC Curve, Area Under Curve, Case-Control Studies, Child, Preschool, Pulmonary artery, Vascular resistance, Cardiology, Female, Cardiology and Cardiovascular Medicine, business |
| الوصف: | Background— Pulsed-wave Doppler determination of the pulmonary artery acceleration time (PAAT) as a surrogate for pulmonary artery pressure was found to be of clinical value for assessment of pulmonary hypertension (PH) with studies to date exclusively performed in adults. This study aims to provide representative, normal reference values for PAAT in children of all ages. Moreover, we validated abnormal PAAT values in 54 children with PH. Methods and Results— We conducted a prospective echocardiographic study in 756 healthy children (aged 1 day to 18 years) and in 54 children with PH. Possible associations of age, body length, body weight, body surface area, and heart rate on PAAT were investigated. The PAAT correlated positively with age ( r =0.848), body length ( r =0.871), body surface area ( r =0.856), and body weight ( r =0.825) and negatively with heart rate ( r =−0.906). PAAT increased with age (neonates: median: 81 ms, range: 53–104; 18th year of life: median: 151 ms, range: 107–187). Receiver operating characteristic analysis for detecting PH patients using age-specific z scores showed an excellent performance of PAAT ( P Conclusions— The PAAT normal reference values and z scores we provide here will be useful to identify children with a shortened PAAT. Abnormal PAAT values with scores |
| تدمد: | 1942-0080 1941-9651 |
| DOI: | 10.1161/circimaging.116.005336 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::905b34323f82b6909db76320bcdb750f https://doi.org/10.1161/circimaging.116.005336 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....905b34323f82b6909db76320bcdb750f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19420080 19419651 |
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| DOI: | 10.1161/circimaging.116.005336 |