Comparing continuous and harmonized measures of depression severity in older adults with bipolar disorder: Relationship to functioning
| العنوان: | Comparing continuous and harmonized measures of depression severity in older adults with bipolar disorder: Relationship to functioning |
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| المؤلفون: | Melis Orhan, Caitlin Millett, Federica Klaus, Hilary P. Blumberg, Farren Briggs, Kuo-Hsuan Chung, Nicole Korten, Kaitlin McManus, Patricia van Oppen, Regan E. Patrick, Kaylee Sarna, Ashley Sutherland, Shang-ying Tsai, Luca M. Villa, Joy Yala, Martha Sajatovic, Katherine E. Burdick, Lisa Eyler, Annemiek Dols |
| المساهمون: | Psychiatry, APH - Mental Health, Amsterdam Neuroscience - Compulsivity, Impulsivity & Attention, Neurology, Amsterdam Neuroscience - Neurodegeneration |
| المصدر: | Journal of Affective Disorders, 314, 44-49. Elsevier the GAGE-BD consortium 2022, ' Comparing continuous and harmonized measures of depression severity in older adults with bipolar disorder : Relationship to functioning ', Journal of Affective Disorders, vol. 314, pp. 44-49 . https://doi.org/10.1016/j.jad.2022.06.074 |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Psychiatric Status Rating Scales, Aging, Psychiatry and Mental health, Clinical Psychology, Bipolar Disorder, Depression, Humans, Aged |
| الوصف: | Objective: Harmonizing different depression severity scales often requires creation of categorical variables that may decrease the sensitivity of the measure. Our aim was to compare the associations between categorical and continuous and harmonized measures of depression and global functioning in a large dataset of older age patients with bipolar disorder (OABD). Method: In the Global Aging & Geriatric Experiments in Bipolar Disorder Database (GAGE-BD) the 17-item Hamilton Depression scale (HAM-D), Montgomery Asberg Depression Rating Scale (MADRS) or the Center for Epidemiological Studies Depression scales (CES-D) was used to assess current depressive symptoms, while the Global Assessment of Functioning (GAF) assessed functional status. Data were harmonized from 8 OABD studies (n = 582). In each subsample, the relationship of depression severity as a continuous and categorical measure was compared to GAF. In the total sample, harmonized ordinal depression categories were compared to GAF. Results: Effect size and variance explained by the model for the categorical measure in the total sample was higher than both the categorical and continuous measure in the CES-D subsample, higher than the categorical but lower than the continuous measure in the HAM-D subsample, and lower than both the categorical and continuous measures in the MADRS subsample. Limitations: All included studies have different inclusion and exclusion criteria, study designs, and differ in aspects of sociodemographic variables. Conclusions: Associations were only slightly larger for the continuous vs categorical measures of depression scales. Harmonizing different depression scales into ordinal categories for analyses is feasible without losing statistical power. |
| اللغة: | English |
| تدمد: | 0165-0327 |
| DOI: | 10.1016/j.jad.2022.06.074 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fe40512783af475b654ca8f9156f78b https://research.vumc.nl/en/publications/6abd3dea-611a-4aee-bfeb-ce5d8c256839 |
| Rights: | RESTRICTED |
| رقم الانضمام: | edsair.doi.dedup.....8fe40512783af475b654ca8f9156f78b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 01650327 |
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| DOI: | 10.1016/j.jad.2022.06.074 |