Plasmodium-associated changes in human odor attract mosquitoes
| العنوان: | Plasmodium-associated changes in human odor attract mosquitoes |
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| المؤلفون: | Khalid B. Beshir, Robert W. Sauerwein, W Richard Mukabana, John A. Pickett, Colin J. Sutherland, Jetske G. de Boer, Teun Bousema, Niels O. Verhulst, John C. Caulfield, Stephen J. Powers, Julian Muwanguzi, Annette O. Busula, James G. Logan, Renate C. Smallegange, Michael A. Birkett, Ailie Robinson, Peter Winskill, Willem Takken, Mirjam A Voets, Daniel K. Masiga |
| المساهمون: | Terrestrial Ecology (TE), University of Zurich, Robinson, Ailie |
| المصدر: | E4218 E4209 Proceedings of the National Academy of Sciences USA, 115, 18, pp. E4209-E4218 Proceedings of the National Academy of Sciences of the United States of America, 115(18), E4209-E4218. National Academy of Sciences Proceedings of the National Academy of Sciences USA, 115, E4209-E4218 Proceedings of the National Academy of Sciences of the United States of America, 115(18), E4209-E4218 Proceedings of the National Academy of Sciences of the United States of America 115 (2018) 18 |
| بيانات النشر: | National Academy of Sciences, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 10078 Institute of Parasitology, 0301 basic medicine, Male, Plasmodium, parasite–vector–host interactions, Nonanal, lnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4], chemistry.chemical_compound, host attractiveness, 600 Technology, Disease biomarkers, VIVAX GAMETOCYTES, Laboratory of Entomology, Child, malaria transmission, IN-VIVO, Multidisciplinary, biology, Anopheles, PE&RC, Multidisciplinary Sciences, Parasite–vector–host interactions, international, Child, Preschool, Science & Technology - Other Topics, Female, Malaria transmission, disease biomarkers, AEDES-AEGYPTI, RAPID DIAGNOSTIC-TESTS, Attractiveness, Host attractiveness, LEISHMANIA-MEXICANA-AMAZONENSIS, HUMAN SKIN EMANATIONS, Zoology, 610 Medicine & health, Aedes aegypti, Mosquito Vectors, QUANTITATIVE PCR, 03 medical and health sciences, FALCIPARUM MALARIA, All institutes and research themes of the Radboud University Medical Center, LUNG-CANCER, parasitic diseases, MD Multidisciplinary, medicine, aldehydes, Animals, Humans, Aldehydes, 1000 Multidisciplinary, Science & Technology, parasite-vector-host interactions, MASS-SPECTROMETRY, biology.organism_classification, medicine.disease, Laboratorium voor Entomologie, Malaria, 030104 developmental biology, Octanal, lnfectious Diseases and Global Health Radboud Institute for Health Sciences [Radboudumc 4], Odor, chemistry, Odorants, 570 Life sciences |
| الوصف: | Malaria parasites (Plasmodium) can change the attractiveness of their vertebrate hosts to Anopheles vectors, leading to a greater number of vector-host contacts and increased transmission. Indeed, naturally Plasmodium-infected children have been shown to attract more mosquitoes than parasite-free children. Here, we demonstrate Plasmodium-induced increases in the attractiveness of skin odor in Kenyan children, and reveal quantitative differences in the production of specific odor components in infected, versus parasite-free, individuals. We found the aldehydes heptanal, octanal and nonanal to be produced in greater amounts by infected individuals, and detected by mosquito antennae. In behavioral experiments, we demonstrated that these, and other, Plasmodium-induced aldehydes enhanced the attractiveness of a synthetic odor blend mimicking ‘healthy’ human odor. Heptanal alone increased the attractiveness of ‘parasite-free’ natural human odor. Should the increased production of these aldehydes by Plasmodium-infected humans lead to increased mosquito biting in a natural setting, this would likely affect the transmission of malaria. |
| وصف الملف: | application/pdf; application/octet-stream; application/vnd.openxmlformats-officedocument.wordprocessingml.document |
| تدمد: | 0027-8424 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f3d1c0cee1584f3d0e0baa8d2771acd http://hdl.handle.net/10044/1/58597 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....8f3d1c0cee1584f3d0e0baa8d2771acd |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 00278424 |
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