Acquired von Willebrand Disease in Patients with High Platelet Counts
| العنوان: | Acquired von Willebrand Disease in Patients with High Platelet Counts |
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| المؤلفون: | P. J. J. Van Genderen, U. Budde |
| المصدر: | Seminars in Thrombosis and Hemostasis. 23:425-431 |
| بيانات النشر: | Georg Thieme Verlag KG, 1997. |
| سنة النشر: | 1997 |
| مصطلحات موضوعية: | Adult, Male, congenital, hereditary, and neonatal diseases and abnormalities, medicine.medical_specialty, Pathogenesis, Myeloproliferative Disorders, Polycythemia vera, Von Willebrand factor, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, hemic and lymphatic diseases, Internal medicine, medicine, Von Willebrand disease, Coagulopathy, Humans, Platelet, Polycythemia Vera, Thrombocytosis, biology, Clinical Laboratory Techniques, Platelet Count, business.industry, Hematology, medicine.disease, von Willebrand Diseases, Endocrinology, Immunology, Linear Models, cardiovascular system, biology.protein, Cardiology and Cardiovascular Medicine, business, circulatory and respiratory physiology |
| الوصف: | For patients with high platelet counts an inverse relationship has been established between platelet counts and large vWf multimers in plasma. Platelets are currently thought to be primarily involved in the pathogenesis of this decrease in plasma large vWf multimers, presumably by binding large vWf multimers, resulting in their effective removal from the circulation and/or by degrading (platelet-bound) vWf. In patients with myeloproliferative disorders associated with high platelet counts, a decrease in large vWf multimers in plasma may potentially compromise primary hemostasis. Patients with reactive thrombocytosis exhibit a similar reduction in large vWf multimers in plasma, but their clinical course is usually not complicated by bleeding, probably as a consequence of increased circulating vWf levels due to the behavior of vWf as a reactive protein, which compensates for the relatively decreased levels of large vWf multimers in plasma. |
| تدمد: | 1098-9064 0094-6176 |
| DOI: | 10.1055/s-2007-996119 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f3a1b8203ef4448a004322508f53f87 https://doi.org/10.1055/s-2007-996119 |
| رقم الانضمام: | edsair.doi.dedup.....8f3a1b8203ef4448a004322508f53f87 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10989064 00946176 |
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| DOI: | 10.1055/s-2007-996119 |