Global tests of haemostasis in critically ill patients with severe sepsis syndrome compared to controls
| العنوان: | Global tests of haemostasis in critically ill patients with severe sepsis syndrome compared to controls |
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| المؤلفون: | Nichola J. Macartney, G. P. Findlay, Roger Luddington, Sarah Lewis, Trevor Baglin, Luis I. Macchiavello, A Saayman, Peter William Collins |
| المصدر: | British Journal of Haematology. 135:220-227 |
| بيانات النشر: | Wiley, 2006. |
| سنة النشر: | 2006 |
| مصطلحات موضوعية: | Adult, medicine.medical_specialty, Thromboplastin, Sepsis, Internal medicine, medicine, Humans, education, Aged, Blood coagulation test, Aged, 80 and over, Hemostasis, education.field_of_study, medicine.diagnostic_test, business.industry, Antithrombin, Thrombin, Hematology, Middle Aged, medicine.disease, Thrombosis, Blood Coagulation Factors, Systemic Inflammatory Response Syndrome, Thromboelastography, Thrombelastography, Surgery, C-Reactive Protein, Cardiology, Coagulation screen, Blood Coagulation Tests, business, Protein C, medicine.drug |
| الوصف: | Haemostatic changes in septic patients are complex, with both procoagulant and anticoagulant changes. Thirty-eight patients with severe sepsis and 32 controls were investigated by coagulation screens, individual factor assays, calibrated automated thrombography (CAT), whole blood low-dose-tissue factor activated (LD-TFA) Rotem and LD-TFA waveform analysis. Thirty-six of 38 patients had an abnormal coagulation screen. The mean levels of factors II, V (P < 0.05), VII, X, XI and XII, antithrombin and protein C (P < 0.01) was decreased in sepsis compared with controls. The mean factor VIII and fibrinogen level (P < 0.001) was increased. CAT in platelet rich and poor plasma showed a prolonged lag time (P < 0.02), decreased peak thrombin (P < 0.02) and delayed time to peak thrombin (P < 0.001) in sepsis patients, however, the endogenous thrombin potential was equivalent in sepsis and controls. In LD-TFA Rotem, septic patients had delayed clot times (P = 0.04) but an increased maximum velocity of clot formation (P < 0.01) and area under the clot elasticity curve (P < 0.01). LD-TFA waveform analysis showed a delayed onset time but an increased rate of clot formation (P < 0.005). In conclusion, global tests of haemostasis suggest that in this patient group, activation of haemostasis is delayed but once initiated thrombin generation and clot formation are normal or enhanced. |
| تدمد: | 1365-2141 0007-1048 |
| DOI: | 10.1111/j.1365-2141.2006.06281.x |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f106bb6c2509cc359d3c9fa688a82a7 https://doi.org/10.1111/j.1365-2141.2006.06281.x |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....8f106bb6c2509cc359d3c9fa688a82a7 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13652141 00071048 |
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| DOI: | 10.1111/j.1365-2141.2006.06281.x |