Management of fracture risk in CKD—traditional and novel approaches
| العنوان: | Management of fracture risk in CKD—traditional and novel approaches |
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| المؤلفون: | Mathias Haarhaus, Louise Aaltonen, Daniel Cejka, Mario Cozzolino, Renate T de Jong, Patrick D'Haese, Pieter Evenepoel, Marie-Hélène Lafage-Proust, Sandro Mazzaferro, Eugene McCloskey, Syazrah Salam, Hanne Skou Jørgensen, Marc Vervloet |
| المساهمون: | CKD-MBD Working Group of the ERA |
| المصدر: | Haarhaus, M, Aaltonen, L, Cejka, D, Cozzolino, M, de Jong, R, D'Haese, P C, Evenepoel, P, Lafage-Proust, M-H, Mazzaferro, S, McCloskey, E, Salam, S, Jørgensen, H M S, Vervloet, M & CKD-MBD Working Group of the ERA 2023, ' Management of fracture risk in CKD – traditional and novel approaches ', Clinical Kidney Journal, vol. 16, no. 3, sfac230 . https://doi.org/10.1093/ckj/sfac230 Clinical Kidney Journal |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | CHRONIC KIDNEY-DISEASE, fracture risk, HEMODIALYSIS-PATIENTS, vitamin D, cinacalcet, parathyroidectomy, renal osteodystrophy, QUALITY-OF-LIFE, Biology, Settore MED/14 - Nefrologia, Transplantation, Science & Technology, calcium, LONG-TERM TREATMENT, biomarkers, bone mineral density, mineral metabolism, QUANTITATIVE COMPUTED-TOMOGRAPHY, HIP FRACTURE, Urology & Nephrology, SECONDARY HYPERPARATHYROIDISM, POSTMENOPAUSAL WOMEN, HR-PQCT, Nephrology, Human medicine, BONE-MINERAL DENSITY, Life Sciences & Biomedicine |
| الوصف: | The coexistence of osteoporosis and chronic kidney disease (CKD) is an evolving healthcare challenge in the face of increasingly aging populations. Globally, accelerating fracture incidence causes disability, impaired quality of life and increased mortality. Consequently, several novel diagnostic and therapeutic tools have been introduced for treatment and prevention of fragility fractures. Despite an especially high fracture risk in CKD, these patients are commonly excluded from interventional trials and clinical guidelines. While management of fracture risk in CKD has been discussed in recent opinion-based reviews and consensus papers in the nephrology literature, many patients with CKD stages 3-5D and osteoporosis are still underdiagnosed and untreated. The current review addresses this potential treatment nihilism by discussing established and novel approaches to diagnosis and prevention of fracture risk in patients with CKD stages 3-5D. Skeletal disorders are common in CKD. A wide variety of underlying pathophysiological processes have been identified, including premature aging, chronic wasting, and disturbances in vitamin D and mineral metabolism, which may impact bone fragility beyond established osteoporosis. We discuss current and emerging concepts of CKD-mineral and bone disorders (CKD-MBD) and integrate management of osteoporosis in CKD with current recommendations for management of CKD-MBD. While many diagnostic and therapeutic approaches to osteoporosis can be applied to patients with CKD, some limitations and caveats need to be considered. Consequently, clinical trials are needed that specifically study fracture prevention strategies in patients with CKD stages 3-5D. ispartof: CLINICAL KIDNEY JOURNAL vol:16 issue:3 pages:456-472 ispartof: location:England status: published |
| وصف الملف: | Electronic-eCollection |
| اللغة: | English |
| تدمد: | 2048-8505 |
| DOI: | 10.1093/ckj/sfac230 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8eda27a705c836a75a9fda1ec9936ea1 https://hdl.handle.net/2434/947113 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....8eda27a705c836a75a9fda1ec9936ea1 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20488505 |
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| DOI: | 10.1093/ckj/sfac230 |