Leptin: role over central nervous system in epilepsy
| العنوان: | Leptin: role over central nervous system in epilepsy |
|---|---|
| المؤلفون: | Laura Mora-Muñoz, Claudio A. Mastronardi, Alejandro Guerrero-Naranjo, Elisa Angélica Rodríguez-Jimenez, Alberto Velez-van-Meerbeke |
| المصدر: | BMC Neuroscience, Vol 19, Iss 1, Pp 1-9 (2018) Doherty, G.H., Obesity and the ageing brain: could leptin play a role in neurodegeneration? (2011) Curr Gerontol Geriatr Res, 2011, p. 8 Repositorio EdocUR-U. Rosario Universidad del Rosario instacron:Universidad del Rosario BMC Neuroscience |
| بيانات النشر: | BMC, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Central Nervous System, 0301 basic medicine, Nervous system, Leptin, Drug Response, Protein Expression, Adipose tissue, Convulsants, Review, Drug Mechanism, Epilepsy, 0302 clinical medicine, Receptor de leptina, Función del cerebro, Medicine, General Neuroscience, lcsh:QP351-495, Leptin Receptor, Data Base, Treatment Outcome, medicine.anatomical_structure, Hypothalamus, Anticonvulsants, Animal studies, Human, Signal Transduction, Disease Association, Central nervous system, lcsh:RC321-571, 03 medical and health sciences, Cellular and Molecular Neuroscience, Leptina, Actividad anticonvulsiva, Animals, Humans, lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, Leptin receptor, Anticonvulsant Activity, business.industry, Nonhuman, medicine.disease, 030104 developmental biology, lcsh:Neurophysiology and neuropsychology, Drug Effect, Drug Efficacy, Brain Function, business, Neuroscience, 030217 neurology & neurosurgery, Anatomía humana, citología, histología, Circuito neuronal |
| الوصف: | Adipose tissue is a dynamic organ with different effects on the body. Many of these effects are mediated by leptin, a hormone strongly involved in regulation of feeding and energy metabolism. It has an important role as a mediator of neuronal excitatory activity and higher brain functions. The aim of this study was to review the association between leptin and cerebral neuronal function, in particular its anticonvulsant or convulsant effects and the possible therapeutic role for treating epilepsy. For this purpose, the databases Pubmed, Science Direct, Elsevier, ResearchGate and Scielo were searched to identify experimental studies, reviews and systematic review articles, published in English, Spanish or Portuguese. Experimental studies and the presence of leptin receptors in nervous system sites other than the hypothalamus suggest an influence on higher brain functions. Indeed several animal studies have demonstrated a role of these channels in epileptiform activity as both anticonvulsive and convulsive effects have been found. The reason for these discrepancies is unclear but provides clear evidence of a potential role of leptin and leptin therapy in epileptiform activity. The association between leptin and brain function demonstrates the importance of peripheral metabolic hormones on central nervous system and opens a new way for the development of novel therapeutic interventions in diseases like epilepsy. Nevertheless further investigations are important to clarify the dynamics and diverse actions of leptin on excitatory regulation in the brain. Electronic supplementary material The online version of this article (10.1186/s12868-018-0453-9) contains supplementary material, which is available to authorized users. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1471-2202 |
| DOI: | 10.1186/s12868-018-0453-9 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d537c0f364ea6a1395a8047532005be http://link.springer.com/article/10.1186/s12868-018-0453-9 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....8d537c0f364ea6a1395a8047532005be |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14712202 |
|---|---|
| DOI: | 10.1186/s12868-018-0453-9 |