Tyssue-type plasminogen activator activity in morphologically normal tissues adjacent to gastrointestinal carcinomas is associated with the degree of tumor progression
| العنوان: | Tyssue-type plasminogen activator activity in morphologically normal tissues adjacent to gastrointestinal carcinomas is associated with the degree of tumor progression |
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| المؤلفون: | Lorenzo Scicolone, Alejandro Scicolone, Gabriel Scicolone, Viviana Sanchez, Liliana Vauthay, Melina Rapacioli, Vladimir Flores, Federico Fuentes |
| المصدر: | CONICET Digital (CONICET) Consejo Nacional de Investigaciones Científicas y Técnicas instacron:CONICET |
| بيانات النشر: | Springer, 2006. |
| سنة النشر: | 2006 |
| مصطلحات موضوعية: | Adult, Male, Cancer Research, Pathology, medicine.medical_specialty, Colon, MORPHOLOGICALLY NORMAL TISSUES, Biology, PROTEASES ACTIVITY, Plasminogen Activators, Internal medicine, PLASMINOGEN ACTIVATOR, purl.org/becyt/ford/3.2 [https], Carcinoma, medicine, Humans, TUMOR PROGRESSION, Aged, Gastrointestinal Neoplasms, Aged, 80 and over, Hematology, Activator (genetics), T-plasminogen activator, Stomach, Rectum, Biological activity, General Medicine, Middle Aged, medicine.disease, Urokinase-Type Plasminogen Activator, medicine.anatomical_structure, GASTROINTESTINAL CARCINOMAS, Oncology, Tumor progression, Tissue Plasminogen Activator, Disease Progression, Female, purl.org/becyt/ford/3 [https], Plasminogen activator |
| الوصف: | Purpose: To investigate whether the level of plasminogen activator (PA) activity assayed in gastrointestinal carcinomas and the "morphologically normal tissues" adjacent to them is associated with the degree of tumor progression. Methods: Tumor and "normal tissues" were obtained from gastrointestinal surgical samples to assess urokinase-type (u-PA) and tissue-type plasminogen activator (t-PA) activities by radial caseinolytic assay and the expression of PA inhibitor-1 (PAI-1) by ELISA. We compared the PA system between the tumor and "normal tissues" and we investigated the existence of correlations between: (a) PA production in the tumor and "normal tissues", (b) different components of the PA system, and (c) PA system and the degree of tumor progression. Results: (1) Total PA activity, u-PA activity and PAI-1 expression are significantly higher in tumor than in "normal tissues", whereas t-PA activity does not differ between them. (2) Total PA activity mainly correlates with u-PA activity in tumor tissues and similarly with u-PA and t-PA activities in "normal tissues". (3) There is a significant association between t-PA activity in tumor and "normal tissues" and the degree of tumor progression. Conclusions: "Morphologically normal tissues" adjacent to carcinomas present abnormal t-PA activity that is associated with the degree of tumor progression. Assaying of this activity could be useful as a predictive parameter. Fil: Scicolone, Gabriel Edgardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia "Prof. Eduardo de Robertis". Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencia; Argentina Fil: Sanchez, Viviana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia "Prof. Eduardo de Robertis". Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencia; Argentina Fil: Vauthay, Liliana Graciela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia "Prof. Eduardo de Robertis". Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencia; Argentina Fil: Fuentes, Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia "Prof. Eduardo de Robertis". Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencia; Argentina Fil: Scicolone, Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia "Prof. Eduardo de Robertis". Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencia; Argentina Fil: Scicolone, Lorenzo. Diego Thompson Hospital; Argentina Fil: Rapacioli, Melina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Favaloro; Argentina Fil: Flores, Domingo Vladimir. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia "Prof. Eduardo de Robertis". Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencia; Argentina. Universidad Favaloro; Argentina |
| وصف الملف: | application/pdf |
| اللغة: | English |
| DOI: | 10.1007/s00432-005-0066-4 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d447f044c8e57f98b7ed93a4b1bfefb https://link.springer.com/article/10.1007/s00432-005-0066-4 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....8d447f044c8e57f98b7ed93a4b1bfefb |
| قاعدة البيانات: | OpenAIRE |
| DOI: | 10.1007/s00432-005-0066-4 |
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