Pharmacogenetics of Drug-Resistant Epilepsy (Review of Literature)
| العنوان: | Pharmacogenetics of Drug-Resistant Epilepsy (Review of Literature) |
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| المؤلفون: | Marianna Makowska, Hanna Romanowicz, Beata Smolarz |
| المصدر: | International Journal of Molecular Sciences International Journal of Molecular Sciences, Vol 22, Iss 11696, p 11696 (2021) |
| بيانات النشر: | MDPI, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Drug, GABA receptors, Candidate gene, ATP Binding Cassette Transporter, Subfamily B, Pharmacogenomic Variants, QH301-705.5, media_common.quotation_subject, Drug Resistance, Drug resistance, Disease, Review, Bioinformatics, Catalysis, Inorganic Chemistry, Epilepsy, drug-resistant epilepsy, CYP2 family, Medicine, Animals, Humans, Physical and Theoretical Chemistry, Biology (General), genes, Molecular Biology, QD1-999, MDR-1, Spectroscopy, media_common, pharmacogenetics, business.industry, Organic Chemistry, ion channels, General Medicine, Drug Resistant Epilepsy, medicine.disease, Computer Science Applications, Pharmacogenomic Testing, Chemistry, Pharmacogenomics, Inactivation, Metabolic, business, Pharmacogenetics |
| الوصف: | Pharmacogenomic studies in epilepsy are justified by the high prevalence rate of this disease and the high cost of its treatment, frequent drug resistance, different response to the drug, the possibility of using reliable methods to assess the control of seizures and side effects of antiepileptic drugs. Candidate genes encode proteins involved in pharmacokinetic processes (drug transporters, metabolizing enzymes), pharmacodynamic processes (receptors, ion channels, enzymes, regulatory proteins, secondary messengers) and drug hypersensitivity (immune factors). This article provides an overview of the literature on the influence of genetic factors on treatment in epilepsy. |
| اللغة: | English |
| تدمد: | 1422-0067 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d40b853014f43b8d59a09dc077cdecb http://europepmc.org/articles/PMC8584095 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....8d40b853014f43b8d59a09dc077cdecb |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14220067 |
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