Cell migration and antigen capture are antagonistic processes coupled by myosin II in dendritic cells
| العنوان: | Cell migration and antigen capture are antagonistic processes coupled by myosin II in dendritic cells |
|---|---|
| المؤلفون: | Yingfan Zhang, Robert S. Adelstein, Ana-Maria Lennon-Duménil, Pablo Vargas, Emmanuel Terriac, Raphaël Voituriez, Maël Le Berre, Matthieu Piel, Marine Bretou, Olivier Bénichou, Mélanie Chabaud, Michael Sixt, Mélina L. Heuzé, Jordan Jacobelli, Paola Solanes, Paolo Maiuri, Mathieu Maurin, Danielle Lankar, Tristan Piolot |
| المساهمون: | Chabaud, M, Heuze, Ml, Bretou, M, Vargas, P, Maiuri, P, Solanes, P, Maurin, M, Terriac, E, Le Berre, M, Lankar, D, Piolot, T, Adelstein, R, Zhang, Yf, Sixt, M, Jacobelli, J, Benichou, O, Voituriez, R, Piel, M, Lennon-Dumenil, Am |
| المصدر: | Nature Communications |
| بيانات النشر: | Nature Publishing Group, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Male, Leukocyte migration, Ovalbumin, Cell, General Physics and Astronomy, Bone Marrow Cells, Article, General Biochemistry, Genetics and Molecular Biology, Motor protein, Mice, 03 medical and health sciences, 0302 clinical medicine, Immune system, Antigen, Cell Movement, MHC class I, Myosin, medicine, Animals, Antigens, 030304 developmental biology, Myosin Type II, 0303 health sciences, Multidisciplinary, biology, Histocompatibility Antigens Class II, Cell migration, Dendritic Cells, General Chemistry, Microfluidic Analytical Techniques, Cathepsins, Corrigenda, Molecular biology, Cell biology, Antigens, Differentiation, B-Lymphocyte, medicine.anatomical_structure, biology.protein, 570 Life sciences, Female, 030217 neurology & neurosurgery |
| الوصف: | The immune response relies on the migration of leukocytes and on their ability to stop in precise anatomical locations to fulfil their task. How leukocyte migration and function are coordinated is unknown. Here we show that in immature dendritic cells, which patrol their environment by engulfing extracellular material, cell migration and antigen capture are antagonistic. This antagonism results from transient enrichment of myosin IIA at the cell front, which disrupts the back-to-front gradient of the motor protein, slowing down locomotion but promoting antigen capture. We further highlight that myosin IIA enrichment at the cell front requires the MHC class II-associated invariant chain (Ii). Thus, by controlling myosin IIA localization, Ii imposes on dendritic cells an intermittent antigen capture behaviour that might facilitate environment patrolling. We propose that the requirement for myosin II in both cell migration and specific cell functions may provide a general mechanism for their coordination in time and space. Dendritic cells alternate between fast and slow migratory behaviours, however in the absence of a component of the antigen processing machinery, migration is uniform and fast. Chabaud et al. now show that slow migration results from the relocalisation of myosin II to the cell front where it promotes antigen capture. |
| وصف الملف: | text |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d2a93a957380d54dd9c33dbe8ed1d13 https://repository.ist.ac.at/476/ |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....8d2a93a957380d54dd9c33dbe8ed1d13 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |