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Montmorillonite K10 Clay Catalyzed Synthesis of Novel β‐Aminocarbonyl Compounds and Their Biological Evaluation

التفاصيل البيبلوغرافية
العنوان: Montmorillonite K10 Clay Catalyzed Synthesis of Novel β‐Aminocarbonyl Compounds and Their Biological Evaluation
المؤلفون: Gottimukkala, Rambabu, Yarragudi Bathal Reddy, Kiran, Yadamari, Tarakeswar, Shaik Ibrahim, Khalivulla, Luiz Claudio Almeida, Barbosa, Vijayaparthasarathi, Vijayakumar
المصدر: Chemistry & Biodiversity. 19
بيانات النشر: Wiley, 2022.
سنة النشر: 2022
مصطلحات موضوعية: Staphylococcus aureus, Aldehydes, Bioengineering, General Chemistry, General Medicine, Biochemistry, Antioxidants, Catalysis, Anti-Bacterial Agents, Molecular Docking Simulation, Bentonite, Escherichia coli, Clay, Molecular Medicine, Amines, Molecular Biology
الوصف: An efficient and reusable green catalyst for the synthesis of β-aminocarbonyl compounds has been developed. In this new and greener approach, β-aminocarbonyl compounds (1a-1r) were obtained by Montmorillonite K10 clay catalyzed reaction of aryl amines, aliphatic/aromatic aldehydes and β-ketoesters. Molecular docking investigations were performed for all compounds (1a-1r) with the proteins PDB ID: 1JIJ and 1KZN for S. aureus and E. coli, respectively. For all compounds good to strong interactions with the active sites were observed. The biological activities of β-aminocarbonyl compounds were further assessed for their antibacterial and antioxidant activities. The results confirmed that β-aminocarbonyl compounds could be further developed into new drugs with potent antibacterial and antioxidant activities.
تدمد: 1612-1880
1612-1872
DOI: 10.1002/cbdv.202200669
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d1599cc86b7d72daf123e97a741eddd
https://doi.org/10.1002/cbdv.202200669
Rights: CLOSED
رقم الانضمام: edsair.doi.dedup.....8d1599cc86b7d72daf123e97a741eddd
قاعدة البيانات: OpenAIRE
الوصف
تدمد:16121880
16121872
DOI:10.1002/cbdv.202200669