Basement Membrane in Human Endometrium: Possible Role of Proteolytic Enzymes in Developing Hyperplasia and Carcinoma
| العنوان: | Basement Membrane in Human Endometrium: Possible Role of Proteolytic Enzymes in Developing Hyperplasia and Carcinoma |
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| المؤلفون: | Fabio Cappuccini, Andrea Galassi, Valerio M. Jasonni, Carlo Flamigni, V. Polli, Carlo Bulletti |
| المصدر: | Annals of the New York Academy of Sciences. 622:376-382 |
| بيانات النشر: | Wiley, 1991. |
| سنة النشر: | 1991 |
| مصطلحات موضوعية: | Adult, Endometrium, Basement Membrane, General Biochemistry, Genetics and Molecular Biology, Extracellular matrix, Plasminogen Activators, Fibrinolytic Agents, History and Philosophy of Science, Epidermal growth factor, medicine, Humans, Basement membrane, Chemistry, General Neuroscience, Proteolytic enzymes, Middle Aged, Transforming Growth Factor alpha, Urokinase-Type Plasminogen Activator, ErbB Receptors, Microbial Collagenase, medicine.anatomical_structure, Endometrial Hyperplasia, Uterine Neoplasms, Collagenase, Cancer research, Female, Immunostaining, Peptide Hydrolases, medicine.drug, Transforming growth factor |
| الوصف: | Basement membranes (BM) are elements of the extracellular matrix that are essential for growth and differentiation of tissues. Several collagenolytic enzymes of tumor cells are involved in degradation of the extracellular matrix; growth and inhibitor factors [e.g. Epidermal Growth Factor (EGF), Transforming Growth Factors alpha and beta (TGF-alpha, beta)] seem to be involved in the extracellular matrix formation and degradation. To establish a possible association between the presence of collagenase (C), urokinase-type plasminogen activator (uPA) and the neoplastic growth of the endometrium, 44 endometrial specimens (14 proliferative, 11 secretive, 7 adenomatous hyperplasia, 12 adenocarcinoma) were studied using immunohistochemistry with antisera for C, uPA, EGF receptors and TGF-alpha. Immunostaining for collagenase revealed a positive reaction in moderately differentiated adeno-carcinoma without staining the normal and hyperplastic endometrium. A progressive increase in uPA immunostaining was observed in proliferative and neoplastic endometrium. TGF-alpha and its receptor (EGFr) were stained in proliferative and more clearly in hyperplastic and carcinomatous endometrium. In conclusion, BM play an important role in proliferation and differentiation of human endometrium; their degradation influences estrogen transportation from blood to the stroma. Endometrial BM degradation is associated with the presence of collagenolytic enzymes and growth factors. |
| تدمد: | 1749-6632 0077-8923 |
| DOI: | 10.1111/j.1749-6632.1991.tb37881.x |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cc675b47add4c4b407cf9536650f8ad https://doi.org/10.1111/j.1749-6632.1991.tb37881.x |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....8cc675b47add4c4b407cf9536650f8ad |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17496632 00778923 |
|---|---|
| DOI: | 10.1111/j.1749-6632.1991.tb37881.x |