Polycomb represses a gene network controlling puberty via modulation of histone demethylase Kdm6b expression
| العنوان: | Polycomb represses a gene network controlling puberty via modulation of histone demethylase Kdm6b expression |
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| المؤلفون: | Sergio R. Ojeda, Hollis Wright, Alejandro Lomniczi, Carlos A. Toro, Carlos F. Aylwin |
| المصدر: | Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021) Scientific Reports |
| بيانات النشر: | Nature Portfolio, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0301 basic medicine, Neuroendocrine diseases, Jumonji Domain-Containing Histone Demethylases, Science, Hypothalamus, Gene regulatory network, Polycomb-Group Proteins, macromolecular substances, Biology, Molecular neuroscience, Article, 03 medical and health sciences, 0302 clinical medicine, Gene expression, Animals, Humans, Gene silencing, Gene Regulatory Networks, Epigenetics in the nervous system, Promoter Regions, Genetic, Psychological repression, Gene, Neurons, Kisspeptins, Multidisciplinary, Systems Biology, Puberty, Polycomb Repressive Complex 2, Promoter, Neurosecretory Systems, Cellular neuroscience, Rats, Cell biology, 030104 developmental biology, Histone, Gene Expression Regulation, biology.protein, Demethylase, Medicine, 030217 neurology & neurosurgery |
| الوصف: | Female puberty is subject to Polycomb Group (PcG)-dependent transcriptional repression. Kiss1, a puberty-activating gene, is a key target of this silencing mechanism. Using a gain-of-function approach and a systems biology strategy we now show that EED, an essential PcG component, acts in the arcuate nucleus of the hypothalamus to alter the functional organization of a gene network involved in the stimulatory control of puberty. A central node of this network is Kdm6b, which encodes an enzyme that erases the PcG-dependent histone modification H3K27me3. Kiss1 is a first neighbor in the network; genes encoding glutamatergic receptors and potassium channels are second neighbors. By repressing Kdm6b expression, EED increases H3K27me3 abundance at these gene promoters, reducing gene expression throughout a gene network controlling puberty activation. These results indicate that Kdm6b repression is a basic mechanism used by PcG to modulate the biological output of puberty-activating gene networks. |
| اللغة: | English |
| تدمد: | 2045-2322 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cbd300584d9a410bee1c078de1bc161 https://doaj.org/article/ae4467b975d841c390296873c72d8528 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....8cbd300584d9a410bee1c078de1bc161 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20452322 |
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