American Association for Cancer Research (AACR), 2023.
سنة النشر:
2023
الوصف:
Supplementary Information PDF file - 24991K, Hyperactivated c-Jun N-terminal Kinase as a Therapeutic Target in pVHL-Deficient Renal Cell Carcinomas. Supplementary Materials and Methods. Six (6) supplementary figures. Two (2) supplementary tables. Supplementary Figure S1. pVHL and HIF1� levels in isogenic pairs of RCC cell lines. Supplementary Figure S2. JNK regulates AP1 activity. Supplementary Figure S3. CARD9 silencing inhibits TAK1 functional activity. Supplementary Figure S4. JNK/AP1-dependent EMT in pVHL-deficient RCCs. Supplementary Figure S5. Changes in expression of cadherins and transcription factors resulting from pharmacologic inhibition of JNK in pVHL-deficient cells Supplementary Figure S6. Inhibition of JNK or c-Jun reduces the invasiveness of pVHL-deficient cells. Supplementary Table 1: Phospho-c-Jun Staining in RCC Specimens