From impulses to maladaptive actions: the insula is a neurobiological gate for the development of compulsive behavior
| العنوان: | From impulses to maladaptive actions: the insula is a neurobiological gate for the development of compulsive behavior |
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| المؤلفون: | Morgane Besson, David Belin, D Howett, Jeffrey W. Dalley, Mickaël Puaud, Bianca Jupp, Trevor W. Robbins, Aude Belin-Rauscent, Stephen J. Sawiak, Daniele Caprioli, M-L Daniel, Colin McKenzie, Barry J. Everitt |
| المساهمون: | University of Cambridge [UK] (CAM), CIC - Poitiers, Université de Poitiers-Centre hospitalier universitaire de Poitiers (CHU Poitiers)-Direction Générale de l'Organisation des Soins (DGOS)-Institut National de la Santé et de la Recherche Médicale (INSERM), National National Institute on Drug Abuse Intramural Research Program, National Institute of Health, Neurobiologie intégrative des Systèmes cholinergiques (NISC), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), It was supported by an INSERM AVENIR grant and a FYSSEN foundation grant to DB. MLD was supported by a PhD fellowship from the Fondation pour la Recherche Médicale (FRM) and ABR was supported by a post-doctoral fellowship from the INSERM. BJE was supported by the United Kingdom Medical Research Council (MRC) Grant 9536855, This research was carried out within the Department of Psychology and the Department of Pharmacology of the University of Cambridge, as well as the INSERM AVENIR team Psychobiology of Compulsive Disorders of the University of Poitiers., Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), Belin, D [0000-0002-7383-372X], Apollo - University of Cambridge Repository |
| المصدر: | Molecular Psychiatry Molecular Psychiatry, Nature Publishing Group, 2016, 21 (4), pp.491-9. ⟨10.1038/mp.2015.140⟩ Molecular Psychiatry, 2016, 21 (4), pp.491-9. ⟨10.1038/mp.2015.140⟩ |
| بيانات النشر: | HAL CCSD, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, Serial reaction time, Obsessive-Compulsive Disorder, Neural substrate, [SDV]Life Sciences [q-bio], Neuropsychological Tests, Choice Behavior, Developmental psychology, [SCCO]Cognitive science, 0302 clinical medicine, 5 - Choice serial reaction time task, MESH: Animals, Insular cortex, Cerebral Cortex, MESH: Neuropsychological Tests, Compulsivity, 3. Good health, Psychiatry and Mental health, Schizophrenia, Compulsive behavior, animals, behavior, addictive, cerebral cortex, choice behavior, compulsive behavior, impulsive behavior, male, neuropsychological tests, obsessive-compulsive disorder, rats, reaction time, molecular biology, psychiatry and mental health, cellular and molecular neuroscience, Compulsive Behavior, MESH: Compulsive Behavior, MESH: Impulsive Behavior, medicine.symptom, Psychology, Impulsivity, Schedule induced polydipsia, MESH: Rats, MESH: Choice Behavior, 03 medical and health sciences, Cellular and Molecular Neuroscience, MESH: Behavior, Addictive, Reaction Time, medicine, Animals, Molecular Biology, MESH: Obsessive-Compulsive Disorder, behavior, [SCCO.NEUR]Cognitive science/Neuroscience, addictive, medicine.disease, MESH: Cerebral Cortex, MESH: Male, Rats, MESH: Reaction Time, Behavior, Addictive, 030104 developmental biology, Endophenotype, Impulsive Behavior, Neuroscience, Insula, 030217 neurology & neurosurgery |
| الوصف: | International audience; Impulsivity is an endophenotype of vulnerability for compulsive behaviors. However, the neural mechanisms whereby impulsivity facilitates the development of compulsive disorders, such as addiction or obsessive compulsive disorder, remain unknown. We first investigated, in rats, anatomical and functional correlates of impulsivity in the anterior insular (AI) cortex by measuring both the thickness of, and cellular plasticity markers in, the AI with magnetic resonance imaging and in situ hybridization of the immediate early gene zif268, respectively. We then investigated the influence of bilateral AI cortex lesions on the high impulsivity trait, as measured in the five-choice serial reaction time task (5-CSRTT), and the associated propensity to develop compulsivity as measured by high drinking levels in a schedule-induced polydipsia procedure (SIP). We demonstrate that the AI cortex causally contributes to individual vulnerability to impulsive-compulsive behavior in rats. Motor impulsivity, as measured by premature responses in the 5-CSRTT, was shown to correlate with the thinness of the anterior region of the insular cortex, in which highly impulsive (HI) rats expressed lower zif268 mRNA levels. Lesions of AI reduced impulsive behavior in HI rats, which were also highly susceptible to develop compulsive behavior as measured in a SIP procedure. AI lesions also attenuated both the development and the expression of SIP. This study thus identifies the AI as a novel neural substrate of maladaptive impulse control mechanisms that may facilitate the development of compulsive disorders. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1359-4184 1476-5578 |
| DOI: | 10.1038/mp.2015.140⟩ |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c9c0dbf060a91c24f50298cbb16215e https://hal-pasteur.archives-ouvertes.fr/pasteur-01573811 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....8c9c0dbf060a91c24f50298cbb16215e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13594184 14765578 |
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| DOI: | 10.1038/mp.2015.140⟩ |