Arylhydrocarbonhydroxylase Inducibility and Smoking Habits in Patients with Laryngeal Carcinomas
| العنوان: | Arylhydrocarbonhydroxylase Inducibility and Smoking Habits in Patients with Laryngeal Carcinomas |
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| المؤلفون: | Simonsson Bg, Erik Trell, Gunnela Nordén, Göran Stiksa, Rolf Korsgaard, Peter Kitzing, Bertil Hood |
| المصدر: | Acta Oto-Laryngologica; 98, pp 368-373 (1984) |
| بيانات النشر: | Informa UK Limited, 1984. |
| سنة النشر: | 1984 |
| مصطلحات موضوعية: | Male, Pathology, medicine.medical_specialty, smoking habits, Smoking habit, Population, Physiology, Arylhydrocarbonhydroxylase, medicine, Carcinoma, Humans, Polycyclic Compounds, In patient, Enzyme inducer, education, Laryngeal Neoplasms, Carcinogen, Aged, education.field_of_study, biology, Genetic heterogeneity, Smoking, General Medicine, Laryngeal Neoplasm, medicine.disease, Phenotype, Otorhinolaryngology, Enzyme Induction, biology.protein, Female, Aryl Hydrocarbon Hydroxylases, laryngeal carcinomas |
| الوصف: | There is considerable evidence that the inducible enzyme aryl hydrocarbon hydroxylase (AHH) plays an important role in the activation of polycyclic aromatic hydrocarbons (PAH) to ultimate carcinogens. In man, a genetic heterogeneity of AHH inducibility has been demonstrated, and correlated to susceptibility to bronchogenic carcinomas following exposure to PAH. We assessed AHH inducibility in a control group of 102 healthy Swedish citizens and in 41 patients with laryngeal carcinomas. Frequencies of the three phenotypes of high, intermediate and low AHH inducibility in our control group; 8.8%, 42.2% and 49%, respectively, did not differ significantly from frequencies found in a white US population. In the laryngeal carcinoma group, there was a statistically highly significant overrepresentation of patients with high AHH inducibility, 36.6%, whereas 43.9% had an intermediate and 19.5% a low level. Most of the patients were heavy smokers. These findings add further support to the concept that susceptibility to PAH-induced carcinomas is associated with high levels of inducible AHH activity. |
| وصف الملف: | application/pdf |
| تدمد: | 1651-2251 0001-6489 |
| DOI: | 10.3109/00016488409107575 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c45fc2537663c22e5cd7a7a178d0980 https://doi.org/10.3109/00016488409107575 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....8c45fc2537663c22e5cd7a7a178d0980 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16512251 00016489 |
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| DOI: | 10.3109/00016488409107575 |