Development of a Promising Method for Producing Oligomeric Mixture of Branched Alkylene Guanidines to Improve Substance Quality and Evaluate Their Antiviral Activity against SARS-CoV-2
| العنوان: | Development of a Promising Method for Producing Oligomeric Mixture of Branched Alkylene Guanidines to Improve Substance Quality and Evaluate Their Antiviral Activity against SARS-CoV-2 |
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| المؤلفون: | Sergei V. Beliakov, Viktor P. Volok, I. S. Ivanov, A. V. Aydakova, S. A. Kedik, D. O. Shatalov, Dmitrii S. Minenkov, Diana A. Akhmedova, Lasse Greiner, Liubov I. Kozlovskaya, Alexander Herbst |
| المصدر: | Molecules Volume 26 Issue 11 Molecules, Vol 26, Iss 3472, p 3472 (2021) |
| بيانات النشر: | MDPI, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Spectrometry, Mass, Electrospray Ionization, 2019-20 coronavirus outbreak, Condensation polymer, Coronavirus disease 2019 (COVID-19), Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), microfluidics, Pharmaceutical Science, Organic chemistry, Residual monomer, microreactor, Antiviral Agents, Guanidines, 01 natural sciences, Article, Analytical Chemistry, Inhibitory Concentration 50, 03 medical and health sciences, chemistry.chemical_compound, QD241-441, Chlorocebus aethiops, Drug Discovery, Animals, Inhibitory concentration 50, antimicrobial resistance, Carbon-13 Magnetic Resonance Spectroscopy, Physical and Theoretical Chemistry, Guanidine, Vero Cells, Guanidine derivatives, 030304 developmental biology, 0303 health sciences, SARS-CoV-2, 010405 organic chemistry, Chemistry, COVID-19, Combinatorial chemistry, 0104 chemical sciences, Chemistry (miscellaneous), antiseptic, antiviral activity, Molecular Medicine, antimicrobial resistance, antiviral activity, polycondensation |
| الوصف: | This paper reports the synthesis of branched alkylene guanidines using microfluidic technologies. We describe the preparation of guanidine derivatives at lower temperatures, and with significantly less time than that required in the previously applicable method. Furthermore, the use of microfluidics allows the attainment of high-purity products with a low residual monomer content, which can expand the range of applications of this class of compounds. For all the samples obtained, the molecular-weight characteristics are calculated, based on which the optimal condensation conditions are established. Additionally, in this work, the antiviral activity of the alkylene guanidine salt against the SARS-CoV-2 virus is confirmed. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1420-3049 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c0cf98d4eb762c9beb5036868486d95 http://europepmc.org/articles/PMC8201297 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....8c0cf98d4eb762c9beb5036868486d95 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14203049 |
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