Demographic and clinical characteristics of severe Covid-19 infections: a cross-sectional study from Mashhad University of Medical Sciences, Iran
| العنوان: | Demographic and clinical characteristics of severe Covid-19 infections: a cross-sectional study from Mashhad University of Medical Sciences, Iran |
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| المؤلفون: | Ladan Goshayeshi, Mina Akbari Rad, Robert Bergquist, Abolghasem Allahyari, Kamila Hashemzadeh, MUMS Covid-19 Research Team, Benyamin Hoseini |
| المصدر: | BMC Infectious Diseases BMC Infectious Diseases, Vol 21, Iss 1, Pp 1-8 (2021) |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Male, Cross-sectional study, Infectious and parasitic diseases, RC109-216, Disease, Comorbidity, 030204 cardiovascular system & hematology, Iran, Logistic regression, 0302 clinical medicine, Medical microbiology, Medicine, 030212 general & internal medicine, Young adult, Child, COVID-19, SARS-COV-2, Aged, 80 and over, Epidemiological characteristics, Middle Aged, Anti-Bacterial Agents, Hospitalization, Infectious Diseases, Treatment Outcome, Cardiovascular Diseases, Child, Preschool, Female, Research Article, Adult, medicine.medical_specialty, Adolescent, Fever, Real-Time Polymerase Chain Reaction, Antiviral Agents, 03 medical and health sciences, Young Adult, Diabetes mellitus, Internal medicine, Diabetes Mellitus, Humans, Aged, business.industry, SARS-CoV-2, Infant, Newborn, COVID-19, Infant, Symptoms, Iran, medicine.disease, COVID-19 Drug Treatment, Cross-Sectional Studies, Dyspnea, Cough, Tropical medicine, business |
| الوصف: | Background Coronavirus Disease 2019 (Covid-19) is expanding worldwide. The characteristics of this infection in patients varies from country to country. To move forward, clinical data on infected patients are needed. Here, we report a comparison between fatalities and recovery of patients with severe Covid-19, based on demographic and clinical characteristics. Methods Between 5 March and 12 May 2020 in Mashhad, Iran, 1278 of 4000 suspected Covid-19 patients were confirmed positive by real-time reverse-transcriptase–polymerase-chain-reaction assay of upper respiratory specimens. We compared the demographic, exposure history and clinical symptoms of 925 survivors and 353 fatal cases with confirmed disease. Results Mean (SD) age for all confirmed patients was 56.9 (18.7) years, 67.1 (15.9) years in fatal cases and 53.0 (18.3) years in survivors. Multivariate logistic regression analysis showed that the outcome of patients was associated with age (odds ratio = 1.049, P = 0.0001, 95% CI = 1.040–1.057). Despite a high burden of Covid-19 infections in the 30–39 and 40–49 year age groups, most of these (89.6 and 87.2%, respectively) recovered. The median (IQR) duration of hospitalization was 9.0 (6.0–14.0) days. The most prevalent co-morbidities were cardiovascular disorders (21%) and diabetes (16.3%). Dyspnoea (72.7%), cough (68.1%) and fever (63.8%) were the most frequent clinical symptoms. Healthcare workers, of whom two (3%) died, comprised 5.2% of infected cases. Combination antiviral and antibiotic therapy was used in 43.0% of cases. Conclusions The characteristics of severe Covid-19 varied substantially between fatal cases and survivors, with diabetes and cardiovascular disorders the most prevalent co-morbidities. In contrast to other studies, there were a higher number of fatalities in younger patients in our setting. |
| تدمد: | 1471-2334 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c0c22c5b0f1a42b1e31bd32b37b23e1 https://pubmed.ncbi.nlm.nih.gov/34233638 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....8c0c22c5b0f1a42b1e31bd32b37b23e1 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14712334 |
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