Long non-coding (lnc)RNA PAPAS overexpression inhibits tumor growth in papillary thyroid carcinoma by downregulating lncRNA HOTTIP
| العنوان: | Long non-coding (lnc)RNA PAPAS overexpression inhibits tumor growth in papillary thyroid carcinoma by downregulating lncRNA HOTTIP |
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| المؤلفون: | Juan Xiao, Jian Luan, Yang Guan, Ge Xiao, Zhaowei Bing |
| المصدر: | Oncology Letters |
| بيانات النشر: | D.A. Spandidos, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, Cancer Research, Oncogene, endocrine system diseases, Cell growth, proliferation, Cell, RNA, Articles, Biology, Cell cycle, Molecular medicine, Thyroid carcinoma, long non-coding RNA HOXA transcript at the distal tip, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, medicine.anatomical_structure, long non-coding RNA pre-ribosomal RNA antisense transcripts, Oncology, Downregulation and upregulation, 030220 oncology & carcinogenesis, Cancer research, medicine, papillary thyroid carcinoma |
| الوصف: | The long non-coding (lnc)RNA pre-ribosomal RNA antisense transcripts (PAPAS) can repress ribosomal RNA synthesis, although its role in human disease is currently unknown. The present study aimed to investigate the function of PAPAS in papillary thyroid carcinoma (PTC). PAPAS was downregulated, while the lncRNA HOXA transcript at the distal tip (HOTTIP) was upregulated in patients with PTC. PAPAS and HOTTIP were inversely associated in PTC. PAPAS overexpression led to the downregulation of HOTTIP in PTC cells, while PAPAS expression was not significantly affected by HOTTIP overexpression, suggesting that PAPAS was upstream of HOTTIP. PAPAS expression level decreased, while HOTTIP expression level increased with the increase of clinical staging. PAPAS overexpression led to the inhibition of cell proliferation, while HOTTIP overexpression increased proliferation of PTC cells, and HOTTIP overexpression decreased the effects of PAPAS overexpression. lncRNA PAPAS overexpression may inhibit tumor growth in papillary thyroid carcinoma by downregulating lncRNA HOTTIP. |
| اللغة: | English |
| تدمد: | 1792-1082 1792-1074 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bfdd8e77219c6db4c21c24ba3194126 http://europepmc.org/articles/PMC7039133 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....8bfdd8e77219c6db4c21c24ba3194126 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17921082 17921074 |
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