Serum zinc levels and multiple health outcomes: Implications for zinc-based biomaterials
| العنوان: | Serum zinc levels and multiple health outcomes: Implications for zinc-based biomaterials |
|---|---|
| المؤلفون: | Yufeng Zheng, Xinhua Qu, Kerong Dai, Bo Jia, Hongtao Yang, Zhifeng Yu, Han Qiao |
| المصدر: | Bioactive Materials, Vol 5, Iss 2, Pp 410-422 (2020) Bioactive Materials |
| بيانات النشر: | KeAi Communications Co., Ltd., 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | medicine.medical_specialty, National Health and Nutrition Examination Survey, 0206 medical engineering, Biomedical Engineering, Arthritis, chemistry.chemical_element, 02 engineering and technology, Zinc, Article, Biomaterials, Internal medicine, Diabetes mellitus, medicine, lcsh:TA401-492, lcsh:QH301-705.5, business.industry, Odds ratio, Serum zinc levels, 021001 nanoscience & nanotechnology, medicine.disease, 020601 biomedical engineering, chemistry, Multiple health outcomes, Zinc-based biomaterials, lcsh:Biology (General), Rheumatoid arthritis, Heart failure, lcsh:Materials of engineering and construction. Mechanics of materials, 0210 nano-technology, business, Dyslipidemia, Biotechnology |
| الوصف: | Background Zinc-based biomaterials, including biodegradable metal, nanoparticles, and coatings used in medical implants release zinc ions that may increase the whole-body and serum zinc concentrations. The impact of serum zinc concentrations on major health outcomes can provide insights for device design and clinical transformation of zinc-based biomaterials. Methods This nationally representative cross-sectional study enrolled participants from the National Health and Nutrition Examination Survey (NHANES, 2011-2014) including 3607 participants. Using unadjusted and multivariate-adjusted logistic regression analyses, two-piecewise linear regression model with a smoothing function and threshold level analysis, we evaluated the associations between elevated serum zinc levels and major health outcomes. Results Elevated serum zinc levels were significantly associated with an increase in total spine and total femur bone mineral density (BMD). Every 10 μg/dL increase was associated with a 1.12-fold increase in diabetes mellitus (DM) and 1.23-fold and 1.29-fold increase in cardiovascular diseases (CVD) and coronary heart disease (CHD), in participants with serum zinc levels ≥ 100 μg/dL. It had no significant linear or nonlinear associations with risk of fractures, congestive heart failure, heart attack, thyroid disease, arthritis, osteoarthritis, rheumatoid arthritis, dyslipidemia and cancer. Conclusion Serum zinc levels are significantly associated with increased BMD in the total spine and total femur, and risk of DM, and CVD/CHD among participants with serum zinc levels ≥100 μg/dL. Graphical abstract Image 1 Highlights • The impact of serum zinc levels on major health outcomes can provide insights for zinc-based biomaterials. • Serum zinc levels are significantly associated with increased BMD in the total spine and total femur. • Serum zinc levels are associated risk of DM, and CHD among participants with serum zinc levels ≥100 μg/dL. |
| اللغة: | English |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b330901c4e556ef5c2f6b4cf7d0711a http://www.sciencedirect.com/science/article/pii/S2452199X20300463 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....8b330901c4e556ef5c2f6b4cf7d0711a |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |