Coxsackievirus Adenovirus Receptor Loss Impairs Adult Neurogenesis, Synapse Content, and Hippocampus Plasticity
| العنوان: | Coxsackievirus Adenovirus Receptor Loss Impairs Adult Neurogenesis, Synapse Content, and Hippocampus Plasticity |
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| المؤلفون: | Jorge Valero, Fabrizio Gardoni, Michel G. Desarménien, João O. Malva, Charleine Zussy, Nicolas Lonjon, Cyril Bories, Giampietro Schiavo, Daniel Henaff, Florence Bernex, Felix Junyent, Jeffrey M. Bergelson, Fabien Loustalot, Y. De Koninck, Sara Salinas, Neus Bayó-Puxan, M. Di Luca, J. Chen, Eric J. Kremer |
| المساهمون: | Institut de Génétique Moléculaire de Montpellier (IGMM), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), Università degli Studi di Milano [Milano] (UNIMI), Centre de recherche de l’Institut universitaire en santé mentale de Québec [Canada] (CERVO), Département de réadaptation (Faculté de médecine de l'Université Laval) [Canada], Faculté de médecine de l'Université Laval [Québec] (ULaval)-Faculté de médecine de l'Université Laval [Québec] (ULaval), University of Coimbra [Portugal] (UC), Institut de Génomique Fonctionnelle (IGF), Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Centre National de la Recherche Scientifique (CNRS), Institut de Recherche en Cancérologie de Montpellier (IRCM - U1194 Inserm - UM), CRLCC Val d'Aurelle - Paul Lamarque-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), BioCampus Montpellier (BCM), Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Children’s Hospital of Philadelphia (CHOP ), Service de Neurochirurgie [Montpellier], CHU Gui de Chauliac [Montpellier]-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Institute of Neurology [London], University College of London [London] (UCL), Pathogénèse et contrôle des infections chroniques (PCCI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Universitaire de Montpellier (CHU Montpellier )-Université de Montpellier (UM) |
| المصدر: | Journal of Neuroscience Journal of Neuroscience, Society for Neuroscience, 2016, 36 (37), pp.9558-9571. ⟨10.1523/JNEUROSCI.0132-16.2016⟩ |
| بيانات النشر: | HAL CCSD, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | 0301 basic medicine, Coxsackievirus, Presynapse, Synapse, 03 medical and health sciences, 0302 clinical medicine, synapse, medicine, Hippocampus (mythology), Receptor, coxsakievirus and adenovirus receptor, Loss function, biology, General Neuroscience, Neurogenesis, Alzheimer's disease, biology.organism_classification, adult neurogenesis, 030104 developmental biology, medicine.anatomical_structure, nervous system, inflammation, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Neuron, Neuroscience, human activities, 030217 neurology & neurosurgery, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology |
| الوصف: | Although we are beginning to understand the late stage of neurodegenerative diseases, the molecular defects associated with the initiation of impaired cognition are poorly characterized. Here, we demonstrate that in the adult brain, the coxsackievirus and adenovirus receptor (CAR) is located on neuron projections, at the presynapse in mature neurons, and on the soma of immature neurons in the hippocampus. In a proinflammatory or diseased environment, CAR is lost from immature neurons in the hippocampus. Strikingly, in hippocampi of patients at early stages of late-onset Alzheimer's disease (AD), CAR levels are significantly reduced. Similarly, in triple-transgenic AD mice, CAR levels in hippocampi are low and further reduced after systemic inflammation. Genetic deletion of CAR from the mouse brain triggers deficits in adult neurogenesis and synapse homeostasis that lead to impaired hippocampal plasticity and cognitive deficits. We propose that post-translational CAR loss of function contributes to cognitive defects in healthy and diseased-primed brains.SIGNIFICANCE STATEMENTThis study addressed the role of the coxsackievirus and adenovirus receptor (CAR), a single-pass cell adhesion molecule, in the adult brain. Our results demonstrate that CAR is expressed by mature neurons throughout the brain. In addition, we propose divergent roles for CAR in immature neurons, during neurogenesis, and at the mature synapse. Notably, CAR loss of function also affects hippocampal plasticity. |
| اللغة: | English |
| تدمد: | 0270-6474 1529-2401 |
| DOI: | 10.1523/JNEUROSCI.0132-16.2016⟩ |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a7cb398e9c9f7d3486bb48f8d81a1ad https://hal.archives-ouvertes.fr/hal-01824497/document |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....8a7cb398e9c9f7d3486bb48f8d81a1ad |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 02706474 15292401 |
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| DOI: | 10.1523/JNEUROSCI.0132-16.2016⟩ |