Huang Qin Hua Shi decoction for high-temperature- and high-humidity-induced cognitive-behavioral disorder in rats is associated with deactivation of the hypothalamic–pituitary–adrenal axis
| العنوان: | Huang Qin Hua Shi decoction for high-temperature- and high-humidity-induced cognitive-behavioral disorder in rats is associated with deactivation of the hypothalamic–pituitary–adrenal axis |
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| المؤلفون: | Yonghe Hu, Xiaolong Zhong, Mingyang Guo, Min Yang, Yong Luo |
| المصدر: | Journal of International Medical Research, Vol 47 (2019) The Journal of International Medical Research |
| بيانات النشر: | SAGE Publishing, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | 0301 basic medicine, Male, Medicine (General), Corticotropin-Releasing Hormone, Pituitary-Adrenal System, Decoction, Biochemistry, Rats, Sprague-Dawley, Behavior disorder, Corticotropin-releasing hormone, 0302 clinical medicine, Glucocorticoid receptor, glucocorticoid receptor, hypothalamic–pituitary–adrenal axis, High humidity, high-temperature and high-humidity stress, Behavior, Animal, Temperature, General Medicine, Pre-Clinical Research Reports, Mifepristone, medicine.anatomical_structure, Phenotype, Corticosteroid, Hypothalamic–pituitary–adrenal axis, hormones, hormone substitutes, and hormone antagonists, medicine.medical_specialty, corticosteroid, Hypothalamo-Hypophyseal System, endocrine system, medicine.drug_class, Adrenocorticotropic hormone, 03 medical and health sciences, Receptors, Glucocorticoid, R5-920, Adrenocorticotropic Hormone, Internal medicine, Huang Qin Hua Shi decoction, medicine, Animals, RNA, Messenger, Maze Learning, business.industry, Biochemistry (medical), Humidity, Cell Biology, 030104 developmental biology, Endocrinology, Gene Expression Regulation, business, Cognition Disorders, Corticosterone, 030217 neurology & neurosurgery, Stress, Psychological, Drugs, Chinese Herbal |
| الوصف: | ObjectiveTo investigate the effects of Huang Qin Hua Shi (HQ) decoction on the hypothalamic–pituitary–adrenal (HPA) axis in rats under high-temperature (hT)- and high-humidity (hH)-induced stress.MethodsMale rats were randomized into four groups: rats without stress; rats induced with hT (35 ± 1°C) and hH (85 ± 5% humidity); rats induced with hT and hH and treated with HQ decoction; and rats induced with hT and hH and treated with mifepristone. After 3 weeks, rats underwent the Morris water maze and open-field test. Rat hypothalami were analyzed pathologically using hematoxylin and eosin staining and glucocorticoid receptor (GR) mRNA expression was evaluated by in situ hybridization. Serum levels of corticotropin-releasing hormone (CRH), adrenocorticotropic hormone (ACTH), and corticosteroid (CORT) were assessed by enzyme-linked immunosorbent assay.ResultsThe administration of mifepristone or HQ in stressed rats significantly improved their performance in the Morris water maze test and increased the central-to-peripheral ratio and incidence of deep rearing in the open-field test. Mifepristone and HQ also reversed histological changes in the hypothalami of stressed rats. Compared with control rats, GR mRNA expression in the hypothalamus and serum CRH, ACTH, and CORT were significantly elevated in rats stressed with hT and hH, and these changes were attenuated by mifepristone and HQ.ConclusionHQ decoction protects against hT- and hH-induced cognitive-behavioral disorder and its therapeutic effect is associated with decreased HPA axis activity. |
| اللغة: | English |
| تدمد: | 1473-2300 0300-0605 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89de6abdf79287e4863a7aab7a74fed3 https://doaj.org/article/b191453f7b8f47bc881ebff4ee0214ed |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....89de6abdf79287e4863a7aab7a74fed3 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14732300 03000605 |
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