Comparison of cancer prevalence between patients with glomerulonephritis and the general population at the time of kidney biopsy
| العنوان: | Comparison of cancer prevalence between patients with glomerulonephritis and the general population at the time of kidney biopsy |
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| المؤلفون: | Hyun Jin Ryu, Jiwon Ryu, Ho Jun Chin, Ki Young Na, Dong Wan Chae, Hyung Jin Yoon, Sejoong Kim |
| المصدر: | PLoS ONE, Vol 14, Iss 10, p e0224024 (2019) PLoS ONE |
| بيانات النشر: | Public Library of Science (PLoS), 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Male, Biopsy, 030232 urology & nephrology, 030204 cardiovascular system & hematology, Kidney, Pathology and Laboratory Medicine, Gastroenterology, 0302 clinical medicine, Focal segmental glomerulosclerosis, Glomerulonephritis, Risk Factors, Neoplasms, Prevalence, Medicine and Health Sciences, Medicine, Minimal change disease, education.field_of_study, Multidisciplinary, Nephritis, medicine.diagnostic_test, Amyloidosis, Age Factors, Middle Aged, Lupus Nephritis, Chemistry, Oncology, Nephrology, Physical Sciences, Female, Anatomy, Multiple Myeloma, Glomerular Filtration Rate, Research Article, Chemical Elements, Adult, Risk, medicine.medical_specialty, Science, Population, Immunology, Renal function, Surgical and Invasive Medical Procedures, Autoimmune Diseases, 03 medical and health sciences, Breast cancer, Signs and Symptoms, Diagnostic Medicine, Internal medicine, Cancer Detection and Diagnosis, Humans, education, Aged, Retrospective Studies, business.industry, Cancer, Biology and Life Sciences, Glomerulonephritis, IGA, Kidneys, Renal System, medicine.disease, Tin, Clinical Immunology, Clinical Medicine, business |
| الوصف: | Glomerulonephritis (GN) has been associated with many solid and hematologic malignancies. However, cancer prevalence at the time of GN diagnosis has been rarely examined. We aimed to evaluate the cancer prevalence in patients with GN at the time of kidney biopsy and to compare the results to those of the general population. A total of 1,155 patients who underwent kidney biopsy between 2003 and 2017 were included. We investigated patients diagnosed with cancer within one month of kidney biopsy. The occurrence of cancer was compared with that of the Korean general population using the observed-to-expected rates (O/E ratio). Twenty-nine patients with GN had cancer. The mean age of patients with and without cancer was 49 and 66 years old, respectively. The proportion of male patients with and without cancer was 49.4% and 58.6%, respectively. The glomerular filtration rate was different between the groups (78.1 ± 37.0, 58.0 ± 43.6 ml/min/1.73 m2, p = 0.006), but the urine protein/creatinine ratio was not (3.21 ± 4.01, 5.38 ± 7.47 g/gCr, p = 0.172). Immunoglobulin A nephropathy (IgAN) was the most common GN (37.9%), followed by membranous GN (13.5%), focal segmental glomerulosclerosis (9.7%), minimal change disease (9.2%), amyloidosis (1.2%). Amyloidosis was the most common GN associated with malignancy (20.7%). In patients with amyloidosis, cancer was observed almost 28 times more than expected and these patients showed higher cancer occurrence than patients with other GN (Relative Risk [RR]: 15.73; 95% confidence interval [CI]: 4.82–51.30; p < 0.01). Cancer occurrence was three times greater in GN patients aged > 50 years compared to the general population (O/E ratio: 3.42; 95% CI: 1.37–5.46; p = 0.027). Patients with GN, especially amyloidosis, have higher risk of cancer than the general population at the time of GN diagnosis. Older age (> 50 years) was one of the major determinants of the presence of cancer in GN patients. |
| اللغة: | English |
| تدمد: | 1932-6203 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::897a2ae64965d5e70dff1c9abddb83fa https://doaj.org/article/503cfeb0014241f4ad1786ade3c3540f |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....897a2ae64965d5e70dff1c9abddb83fa |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19326203 |
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