Increased Progesterone Receptor Expression in Benign Epithelium of BRCA1 -Related Breast Cancers
| العنوان: | Increased Progesterone Receptor Expression in Benign Epithelium of BRCA1 -Related Breast Cancers |
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| المؤلفون: | Mark E. Robson, Weiwei Li, Crispinita D. Arroyo, Jeff Boyd, K. S. Panageas, Narciso Olvera, Mary L. Gemignani, Dilip Giri, Kenneth Offit, Faina Bogomolniy, Patrick I. Borgen, Tari A. King |
| المصدر: | Cancer Research. 64:5051-5053 |
| بيانات النشر: | American Association for Cancer Research (AACR), 2004. |
| سنة النشر: | 2004 |
| مصطلحات موضوعية: | Adult, Cancer Research, endocrine system diseases, Mammary gland, Breast Neoplasms, Biology, medicine.disease_cause, Immunoenzyme Techniques, Breast cancer, Progesterone receptor, medicine, Humans, Neoplasm Invasiveness, skin and connective tissue diseases, Aged, BRCA2 Protein, BRCA1 Protein, Carcinoma, Ductal, Breast, BRCA mutation, Epithelial Cells, Middle Aged, medicine.disease, Epithelium, Carcinoma, Lobular, medicine.anatomical_structure, Oncology, Hormone receptor, Disease Progression, Cancer research, Female, Receptors, Progesterone, Carcinogenesis, Haploinsufficiency |
| الوصف: | The study of pathologically normal breast epithelium of BRCA mutation carriers may yield insights into the early natural history of breast tumorigenesis. Hormone receptor expression was assessed in 24 cases of invasive breast cancer associated with a mutation in BRCA1 (n = 15) or BRCA2 (n = 9) and in 39 sporadic cases matched for patient age and tumor hormone receptor status. Expression of progesterone receptor was significantly (P = 0.0003) more common in normal breast epithelium adjacent to invasive breast carcinoma in BRCA1-linked cases compared with sporadic cases. The wild-type BRCA allele was retained in normal epithelium of all cases tested. We conclude that deregulation of progesterone receptor expression, as a result of BRCA1 haploinsufficiency, may represent an early event in BRCA1-linked breast tumorigenesis. |
| تدمد: | 1538-7445 0008-5472 |
| DOI: | 10.1158/0008-5472.can-04-1283 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8835e70f05a0f1a2a17b7dc5119ec219 https://doi.org/10.1158/0008-5472.can-04-1283 |
| رقم الانضمام: | edsair.doi.dedup.....8835e70f05a0f1a2a17b7dc5119ec219 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15387445 00085472 |
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| DOI: | 10.1158/0008-5472.can-04-1283 |