Reduction in Urinary Chemokine (C-C Motif) Ligand 2 (CCL2) After Surgery-Induced Weight Loss
| العنوان: | Reduction in Urinary Chemokine (C-C Motif) Ligand 2 (CCL2) After Surgery-Induced Weight Loss |
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| المؤلفون: | Asrul Abdul Wahab, Reynu Rajan, Nik Ritza Kosai, Rozita Mohd, Guo Hou Loo, Surita Binti Said, Shamsul Azhar Shah |
| المصدر: | Scientific Reports, Vol 10, Iss 1, Pp 1-6 (2020) Scientific Reports |
| بيانات النشر: | Nature Publishing Group, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Sleeve gastrectomy, Urinary system, medicine.medical_treatment, Gastric Bypass, Renal function, lcsh:Medicine, 030209 endocrinology & metabolism, Urine, Anastomosis, Article, 03 medical and health sciences, 0302 clinical medicine, Gastrectomy, Weight loss, Chronic kidney disease, Weight Loss, medicine, Albuminuria, Humans, Obesity, Prospective Studies, 030212 general & internal medicine, Prospective cohort study, lcsh:Science, Chemokine CCL2, Multidisciplinary, business.industry, lcsh:R, Diagnostic markers, Venous blood, Middle Aged, Surgery, Female, Laparoscopy, lcsh:Q, medicine.symptom, business, Glomerular Filtration Rate |
| الوصف: | Kidney dysfunction, a deleterious effect of obesity, is now recognized as a relevant health risk. Chemokine (C-C Motif) Ligand 2 (CCL2) is one of the critical chemokines that play a vital role in the development of obesity-related metabolic disease. We aim to measure the changes in urinary CCL2 in our patients before and after their bariatric procedure and examine the correlation between CCL2 and renal function. A prospective cohort study was conducted at our teaching university hospital. Ethics approval was obtained from our institutional review board. Patients with a BMI of ≥37.5 kg/m2 with no history of renal disease were included. They underwent single anastomosis gastric bypass (SAGB), Roux-en-Y gastric bypass (RYGB) or sleeve gastrectomy (SG), all performed via laparoscopic approach. Venous blood and urine samples were obtained preoperatively and six months after surgery. A total of 58 patients were recruited, with SG being performed in 74.1% of patients. At six-months follow-up, median (IQR) body weight reduced from 101.35 kgs (20.25) to 76.95 kg (24.62) p 2, p p 0·001. There is a significant correlation between the reduction of BMI and the reduction of urinary CCL2 (r = −0.220, p = 0.048). We also found a significant correlation between the reduction of urinary CCL2 with the reduction of urine ACR (r = −0.240, p = 0.035). Urinary CCL2 is a promising biomarker that can be used to assess improvement in renal function in obese patients after bariatric surgery. |
| اللغة: | English |
| تدمد: | 2045-2322 |
| DOI: | 10.1038/s41598-020-57763-8 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::882f2116049b23d124fa2245a2bd3add http://link.springer.com/article/10.1038/s41598-020-57763-8 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....882f2116049b23d124fa2245a2bd3add |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20452322 |
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| DOI: | 10.1038/s41598-020-57763-8 |