Prescription of Valproate-Containing Medicines in Women of Childbearing Potential who have Psychiatric Disorders: Is It Worth the Risk?
| العنوان: | Prescription of Valproate-Containing Medicines in Women of Childbearing Potential who have Psychiatric Disorders: Is It Worth the Risk? |
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| المؤلفون: | David S. Baldwin, Hugo J F Amaro |
| المصدر: | CNS Drugs. 34:163-169 |
| بيانات النشر: | Springer Science and Business Media LLC, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | medicine.medical_specialty, Prescription Drugs, Neurology, Childbearing Potential, MEDLINE, 03 medical and health sciences, 0302 clinical medicine, Pharmacotherapy, mental disorders, Humans, Medicine, Women, Pharmacology (medical), Medical prescription, Psychiatry, business.industry, Mental Disorders, Valproic Acid, medicine.disease, 030227 psychiatry, Psychiatry and Mental health, Tolerability, Autism spectrum disorder, Anticonvulsants, Female, Neurology (clinical), Psychopharmacology, business, 030217 neurology & neurosurgery |
| الوصف: | Valproate-containing medicines have long been used in psychiatric practice, principally in the treatment of acute manic episodes, as augmentation agents in the treatment of bipolar and unipolar depressive episodes, and in the prophylaxis of bipolar affective disorder. Many babies are still being born with the adverse consequences of valproate exposure in utero, which include congenital malformations, neurodevelopmental delay, and increased risks of attention-deficit hyperactivity disorder and autism spectrum disorder. Previous measures designed to better inform women about the risks associated with valproate have not been sufficiently effective. This review highlights recent recommendations from influential regulatory and advisory bodies, summarises the relative efficacy and tolerability of valproate preparations in the psychiatric conditions for which they have often been prescribed, and offers practical guidance for the withdrawal and replacement of valproate-containing medicines in women with psychiatric disorders. |
| تدمد: | 1179-1934 1172-7047 |
| DOI: | 10.1007/s40263-019-00694-4 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87cd36f82902510957815886b3933850 https://doi.org/10.1007/s40263-019-00694-4 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....87cd36f82902510957815886b3933850 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 11791934 11727047 |
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| DOI: | 10.1007/s40263-019-00694-4 |