Palladium‐Catalyzed Construction of Quaternary Stereocenters by Enantioselective Arylation of γ‐Lactams with Aryl Chlorides and Bromides
| العنوان: | Palladium‐Catalyzed Construction of Quaternary Stereocenters by Enantioselective Arylation of γ‐Lactams with Aryl Chlorides and Bromides |
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| المؤلفون: | Carina I. Jette, Masaki Hayashi, Hideki Shimizu, Irina Geibel, Jeremy B. Morgan, Brian M. Stoltz, Shunya Sakurai, Shoshana Bachman |
| المصدر: | Angewandte Chemie International Edition. 58:4297-4301 |
| بيانات النشر: | Wiley, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Lactams, chemistry.chemical_element, 010402 general chemistry, Hydrocarbons, Aromatic, 01 natural sciences, Catalysis, Stereocenter, chemistry.chemical_compound, Hydrocarbons, Chlorinated, Molecular Structure, 010405 organic chemistry, Ligand, Aryl, Enantioselective synthesis, Stereoisomerism, General Medicine, General Chemistry, Combinatorial chemistry, Hydrocarbons, Brominated, 0104 chemical sciences, chemistry, Yield (chemistry), Electrophile, Palladium |
| الوصف: | Herein, we report the first Pd‐catalyzed enantioselective arylation of α‐substituted γ‐lactams. Two sets of conditions were developed for this transformation, allowing for the use of either aryl chlorides or bromides as electrophiles. Utilizing a highly electron‐rich, dialkylphosphine ligand, we have been able to construct α‐quaternary centers in good yields (up to 91% yield) and high enantioselectivities (up to 97% ee). |
| وصف الملف: | application/pdf |
| تدمد: | 1521-3773 1433-7851 |
| DOI: | 10.1002/anie.201814475 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87cbc014ea5efe4213279ea1e281d180 https://doi.org/10.1002/anie.201814475 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....87cbc014ea5efe4213279ea1e281d180 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15213773 14337851 |
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| DOI: | 10.1002/anie.201814475 |