Adiponectin Decreases Gastric Smooth Muscle Cell Excitability in Mice
| العنوان: | Adiponectin Decreases Gastric Smooth Muscle Cell Excitability in Mice |
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| المؤلفون: | Valdo Ricca, Eglantina Idrizaj, Maria Caterina Baccari, Roberta Squecco, Fabio Francini, Rachele Garella, Giovanni Castellini |
| المصدر: | Frontiers in Physiology Frontiers in Physiology, Vol 10 (2019) |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 0301 basic medicine, medicine.medical_specialty, Physiology, Central nervous system, Cell, Adipokine, Inhibitory postsynaptic potential, gastric fundus, lcsh:Physiology, 03 medical and health sciences, 0302 clinical medicine, Physiology (medical), Internal medicine, medicine, membrane properties, Membrane potential, Adiponectin, lcsh:QP1-981, adiponectin, Chemistry, Brief Research Report, Peripheral, Electrophysiology, 030104 developmental biology, medicine.anatomical_structure, Endocrinology, adiponectin, gastric smooth muscle cell, 030220 oncology & carcinogenesis, satiety signals, ion currents |
| الوصف: | Some adipokines known to regulate food intake at a central level can also affect gastrointestinal motor responses. These are recognized to be peripheral signals able to influence feeding behavior as well. In this view, it has been recently observed that adiponectin (ADPN), which seems to have a role in sending satiety signals at the central nervous system level, actually affects the mechanical responses in gastric strips from mice. However, at present, there are no data in the literature about the electrophysiological effects of ADPN on gastric smooth muscle. To this aim, we achieved experiments on smooth muscle cells (SMCs) of gastric fundus to find out a possible action on SMC excitability and on membrane phenomena leading to the mechanical response. Experiments were made inserting a microelectrode in a single cell of a muscle strip of the gastric fundus excised from adult female mice. We found that ADPN was able to hyperpolarize the resting membrane potential, to enhance the delayed rectifier K+ currents and to reduce the voltage-dependent Ca2+ currents. Our overall results suggest an inhibitory action of ADPN on gastric SMC excitation-contraction coupling. In conclusion, the depressant action of ADPN on the gastric SMC excitability, here reported for the first time, together with its well-known involvement in metabolism, might lead us to consider a possible contribution of ADPN also as a peripheral signal in the hunger-satiety cycle and thus in feeding behavior. |
| تدمد: | 1664-042X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87a6894a2a796069fd121ab0f2f4065a https://pubmed.ncbi.nlm.nih.gov/31447692 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....87a6894a2a796069fd121ab0f2f4065a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1664042X |
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