التفاصيل البيبلوغرافية
العنوان:
Design, synthesis, and SAR of heterocycle-containing antagonists of the human CCR5 receptor for the treatment of HIV-1 infection
المؤلفون:
Anthony Carella , Janet Lineberger , Karen Holmes , Julie A. DeMartino , Sandra L. Gould , Liping Wang , Ping Chen , Paul E. Finke , Gwen Carver , Daria J. Hazuda , Sander G. Mills , Michael W. Miller , William A. Schleif , Martin S. Springer , Emilio A. Emini , Bryan Oates , Renee Danzeisen , Lorraine Malkowitz , Malcolm MacCoss , Joseph Kessler , Charles G. Caldwell , Dooseop Kim
المصدر:
Bioorganicmedicinal chemistry letters . 11(24)
سنة النشر:
2001
مصطلحات موضوعية:
Stereochemistry , Chemokine receptor CCR5 , Anti-HIV Agents , Clinical Biochemistry , Human immunodeficiency virus (HIV) , Pharmaceutical Science , Hydantoin , HIV Infections , medicine.disease_cause , Biochemistry , Chemical synthesis , chemistry.chemical_compound , Structure-Activity Relationship , Heterocyclic Compounds , Drug Discovery , medicine , Moiety , Humans , Molecular Biology , biology , Bicyclic molecule , Organic Chemistry , Antagonist , In vitro , chemistry , CCR5 Receptor Antagonists , biology.protein , HIV-1 , Molecular Medicine , HeLa Cells
الوصف:
Replacement of the large hydantoin-indole moiety from our previous work with a variety of smaller heterocyclic analogues gave rise to potent CCR5 antagonists having binding affinity comparable to the hydantoin analogues. The synthesis, SAR, and biological profiles of this class of antagonists are described.
تدمد:
0960-894X
URL الوصول:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::876a0d2c5760789981555e569f57bcbe https://pubmed.ncbi.nlm.nih.gov/11720852
Rights:
CLOSED
رقم الانضمام:
edsair.doi.dedup.....876a0d2c5760789981555e569f57bcbe
قاعدة البيانات:
OpenAIRE