Characterization of Sex Determination and Sex Differentiation Genes in Latimeria
| العنوان: | Characterization of Sex Determination and Sex Differentiation Genes in Latimeria |
|---|---|
| المؤلفون: | Schmidt, Jennifer V., Mariko, Forconi, Adriana, Canapa, Marco, Barucca, Biscotti, Maria A., Teresa, Capriglione, Francesco, Buonocore, Fausto, Anna M., Makapedua, Daisy M., Pallavicini, Alberto, Gerdol, Marco, DE MORO, Gianluca, Giuseppe, Scapigliati, Ettore, Olmo, Manfred, Schartl |
| المساهمون: | Mariko, Forconi, Adriana, Canapa, Marco, Barucca, Maria Assunta, Biscotti, Capriglione, Teresa, Francesco, Buonocore, Anna Maria, Fausto, Daisy Monica, Makapedua, Alberto, Pallavicini, Marco, Gerdol, Gianluca De, Moro, Giuseppe, Scapigliati, Ettore, Olmo, Manfred, Schartl, Jennifer V., Schmidt, Maria A., Biscotti, Teresa, Capriglione, Anna M., Fausto, Daisy M., Makapedua, Pallavicini, Alberto, Gerdol, Marco, DE MORO, Gianluca |
| المصدر: | PLoS ONE PLoS ONE, Vol 8, Iss 4, p e56006 (2013) |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | Male, aromatase, fibroblast growth factor 16, fibroblast growth factor 9, transcription factor Sox10, transcription factor Sox8, transcription factor Sox9, transcriptome, Wnt4 protein, Sex Differentiation, Gene regulatory network, Gene Expression, Genome, Transcriptomes, Transcriptome, transcription factor Sox8, Mice, transcription factor Sox9, Transforming Growth Factor beta, Morphogenesis, Genetics, Sexual Differentiation, Multidisciplinary, biology, Latimeria, Fishes, Genomics, Animal Models, Medicine, Female, Wnt4 protein, Research Article, Fish Proteins, aromatase, Evolutionary Processes, Lineage (genetic), transcription factor Sox10, Science, Molecular Sequence Data, Marine Biology, Model Organisms, Genome Analysis Tools, Animals, Humans, Amino Acid Sequence, ddc:610, Biology, Gene, Evolutionary Biology, Sexual differentiation, fibroblast growth factor 16, Gene Expression Profiling, fibroblast growth factor 9, Computational Biology, Sex Determination, Sex Determination Processes, Comparative Genomics, biology.organism_classification, Animal Genetics, Zoology, transcriptome, Developmental Biology |
| الوصف: | Genes involved in sex determination and differentiation have been identified in mice, humans, chickens, reptiles, amphibians and teleost fishes. However, little is known of their functional conservation, and it is unclear whether there is a common set of genes shared by all vertebrates. Coelacanths, basal Sarcopterygians and unique “living fossils”, could help establish an inventory of the ancestral genes involved in these important developmental processes and provide insights into their components. In this study 33 genes from the genome of Latimeria chalumnae and from the liver and testis transcriptomes of Latimeria menadoensis, implicated in sex determination and differentiation, were identified and characterized and their expression levels measured. Interesting findings were obtained for GSDF, previously identified only in teleosts and now characterized for the first time in the sarcopterygian lineage; FGF9, which is not found in teleosts; and DMRT1, whose expression in adult gonads has recently been related to maintenance of sexual identity. The gene repertoire and testis-specific gene expression documented in coelacanths demonstrate a greater similarity to modern fishes and point to unexpected changes in the gene regulatory network governing sexual development. |
| وصف الملف: | ELETTRONICO; application/pdf |
| اللغة: | English |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::872f972f6a86bcc232c990385781b597 http://hdl.handle.net/11368/2682749 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....872f972f6a86bcc232c990385781b597 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |