Dopamine neurons encode the better option in rats deciding between differently delayed or sized rewards
| العنوان: | Dopamine neurons encode the better option in rats deciding between differently delayed or sized rewards |
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| المؤلفون: | Geoffrey Schoenbaum, Matthew R. Roesch, Donna J. Calu |
| المصدر: | Nature Neuroscience. 10:1615-1624 |
| بيانات النشر: | Springer Science and Business Media LLC, 2007. |
| سنة النشر: | 2007 |
| مصطلحات موضوعية: | Male, Apomorphine, Dopamine, Action Potentials, Choice Behavior, Brain mapping, Article, Reward system, Reward, Predictive Value of Tests, medicine, Animals, Rats, Long-Evans, Neurons, Systems neuroscience, Analysis of Variance, Brain Mapping, Behavior, Animal, General Neuroscience, Ventral Tegmental Area, Time perception, Rats, Ventral tegmental area, medicine.anatomical_structure, Dopamine Agonists, Odorants, Time Perception, Conditioning, Operant, PVLV, Neuron, Cues, Psychology, Neuroscience, psychological phenomena and processes, Cognitive psychology, medicine.drug |
| الوصف: | The dopamine system is thought to be involved in making decisions about reward. Here we recorded from the ventral tegmental area in rats learning to choose between differently delayed and sized rewards. As expected, the activity of many putative dopamine neurons reflected reward prediction errors, changing when the value of the reward increased or decreased unexpectedly. During learning, neural responses to reward in these neurons waned and responses to cues that predicted reward emerged. Notably, this cue-evoked activity varied with size and delay. Moreover, when rats were given a choice between two differently valued outcomes, the activity of the neurons initially reflected the more valuable option, even when it was not subsequently selected. |
| تدمد: | 1546-1726 1097-6256 |
| DOI: | 10.1038/nn2013 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86fc3791ed3237e4b77c86d3ab61e225 https://doi.org/10.1038/nn2013 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....86fc3791ed3237e4b77c86d3ab61e225 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15461726 10976256 |
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| DOI: | 10.1038/nn2013 |