Prediction of cancer specific survival after radical nephroureterectomy for upper tract urothelial carcinoma: development of an optimized postoperative nomogram using decision curve analysis
| العنوان: | Prediction of cancer specific survival after radical nephroureterectomy for upper tract urothelial carcinoma: development of an optimized postoperative nomogram using decision curve analysis |
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| المؤلفون: | Christopher G. Wood, Thomas Seisen, Olivier Cussenot, Adil Ouzzane, Francesco Montorsi, Juan Ignacio Martínez-Salamanca, Christian Bolenz, Thomas J. Walton, Morgan Rouprêt, Mesut Remzi, Yair Lotan, Giacomo Novara, Shahrokh F. Shariat, Evanguelos Xylinas, Karim Bensalah, David R. Yates, Vincent Hupertan, Jay D. Raman, Richard Zigeuner, Harun Fajkovic, François Rozet, Vitaly Margulis, Pierre Colin, Hans-Martin Fritsche, Pierre I. Karakiewicz, Wassim Kassouf |
| المساهمون: | Service d'Urologie [CHU Pitié-Salpêtrière], CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Service d'urologie, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-AP-HP - Hôpital Bichat - Claude Bernard [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Service d'urologie [Mondor], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Henri Mondor-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Department of Urology, University of Texas Southwestern Medical Center [Dallas]- The University of Texas Health Science Center at Houston (UTHealth), Medical University Graz, Hospital Weinviertel-Korneuburg-Landesklinikum Korneuburg, Mannheim Medical Center, Universität Heidelberg [Heidelberg], MD Anderson Cancer Center, The University of Texas Health Science Center at Houston (UTHealth), Service d'urologie [Rennes] = Urology [Rennes], Hôpital Pontchaillou-CHU Pontchaillou [Rennes], Cancer Prognostics and Health Outcome Unit, Université de Montréal (UdeM), Department of urology, Università Vita-Salute San Raffaele, French National Database on Upper Tract Tumors, Upper Tract Urothelial Carcinoma Collaboration, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Universität Heidelberg [Heidelberg] = Heidelberg University, Service d'urologie et transplantation rénales [CHU Pitié-Salpêtrière], Sorbonne Université-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service d'urologie [Rennes], Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Hôpital Pontchaillou-CHU Pontchaillou [Rennes], Roupret, M, Hupertan, V, Seisen, T, Colin, P, Xylinas, E, Yates, Dr, Fajkovic, H, Lotan, Y, Raman, Jd, Zigeuner, R, Remzi, M, Bolenz, C, Novara, G, Kassouf, W, Ouzzane, A, Rozet, F, Cussenot, O, Martinez Salamanca, Ji, Fritsche, Hm, Walton, Tj, Wood, Cg, Bensalah, K, Karakiewicz, Pi, Montorsi, Francesco, Margulis, V, Shariat, Sf |
| المصدر: | Journal of Urology Journal of Urology, Elsevier, 2013, 189 (5), pp.1662-9. ⟨10.1016/j.juro.2012.10.057⟩ Journal of Urology, 2013, 189 (5), pp.1662-9. ⟨10.1016/j.juro.2012.10.057⟩ |
| بيانات النشر: | HAL CCSD, 2013. |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | Male, Lymphovascular invasion, 030232 urology & nephrology, MESH: Kidney Pelvis, carcinoma, Nephrectomy, [SDV.MHEP.UN]Life Sciences [q-bio]/Human health and pathology/Urology and Nephrology, 0302 clinical medicine, MESH: Aged, 80 and over, ureter, kidney pelvis, transitional cell, survival, nomograms, MESH: Ureteral Neoplasms, Aged, 80 and over, MESH: Aged, MESH: Middle Aged, Middle Aged, Kidney Neoplasms, 3. Good health, medicine.anatomical_structure, MESH: Ureter, 030220 oncology & carcinogenesis, Cohort, Female, [SDV.IB]Life Sciences [q-bio]/Bioengineering, medicine.medical_specialty, Urology, MESH: Nomograms, Decision Support Techniques, 03 medical and health sciences, Ureter, medicine, Carcinoma, Humans, Aged, Retrospective Studies, MESH: Carcinoma, Transitional Cell, Carcinoma, Transitional Cell, MESH: Humans, Ureteral Neoplasms, business.industry, Carcinoma in situ, Cancer, MESH: Decision Support Techniques, Retrospective cohort study, MESH: Retrospective Studies, Nomogram, medicine.disease, MESH: Male, Surgery, MESH: Nephrectomy, MESH: Kidney Neoplasms, business, MESH: Female |
| الوصف: | International audience; PURPOSE: We conceived and proposed a unique and optimized nomogram to predict cancer specific survival after radical nephroureterectomy in patients with upper tract urothelial carcinoma by merging the 2 largest multicenter data sets reported in this population. MATERIALS AND METHODS: The international and the French national collaborative groups on upper tract urothelial carcinoma pooled data on 3,387 patients treated with radical nephroureterectomy for whom full data for nomogram development were available. The merged study population was randomly split into the development cohort (2,371) and the external validation cohort (1,016). Cox regressions were used for univariable and multivariable analyses, and to build different models. The ultimate reduced nomogram was assessed using Harrell's concordance index (c-index) and decision curve analysis. RESULTS: Of the 2,371 patients in the nomogram development cohort 510 (21.5%) died of upper tract urothelial carcinoma during followup. The actuarial cancer specific survival probability at 5 years was 73.7% (95% CI 71.9-75.6). Decision curve analysis revealed that the use of the best model was associated with benefit gains relative to the prediction of cancer specific survival. The optimized nomogram included only 5 variables associated with cancer specific survival on multivariable analysis, those of age (p = 0.001), T stage (p |
| اللغة: | English |
| تدمد: | 0022-5347 |
| DOI: | 10.1016/j.juro.2012.10.057⟩ |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86f0b5822f07caf40d3b20a8c75461c9 https://hal.archives-ouvertes.fr/hal-00880504 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....86f0b5822f07caf40d3b20a8c75461c9 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 00225347 |
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| DOI: | 10.1016/j.juro.2012.10.057⟩ |