Preventive Effects of Green Tea Extract against Obesity Development in Zebrafish
| العنوان: | Preventive Effects of Green Tea Extract against Obesity Development in Zebrafish |
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| المؤلفون: | Djong-Chi Chu, Norihiro Nishimura, Hiroko Nakayama, Yasuhito Shimada, Liqing Zang, Junya Kuroyanagi, Young Il Kim, Lekh Raj Juneja, Hirotaka Katsuzaki |
| المصدر: | Molecules, Vol 26, Iss 2627, p 2627 (2021) Molecules Volume 26 Issue 9 |
| بيانات النشر: | MDPI AG, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | obesity, Pharmaceutical Science, Adipose tissue, Organic chemistry, Green tea extract, Intra-Abdominal Fat, Pharmacology, 010402 general chemistry, 01 natural sciences, Article, stat, Analytical Chemistry, Mibyo, Transcriptome, QD241-441, Downregulation and upregulation, Drug Discovery, Animals, Medicine, Physical and Theoretical Chemistry, green tea extract, visceral adipose tissue, Zebrafish, Tea, biology, Plant Extracts, 010405 organic chemistry, business.industry, Organ Size, Lipid Metabolism, medicine.disease, biology.organism_classification, zebrafish, Obesity, 0104 chemical sciences, Adipose Tissue, Chemistry (miscellaneous), Molecular Medicine, Signal transduction, RNA-seq, business, Biomarkers, Signal Transduction |
| الوصف: | Various natural products (NPs) have been used to treat obesity and related diseases. However, the best way to fight obesity is preventive, with accurate body weight management through exercise, diet, or bioactive NPs to avoid obesity development. We demonstrated that green tea extract (GTE) is an anti-obesity NP using a zebrafish obesity model. Based on a hypothesis that GTE can prevent obesity, the objective of this study was to assess GTE’s ability to attenuate obesity development. Juvenile zebrafish were pretreated with GTE for seven days before obesity induction via a high-fat diet adult zebrafish were pretreated with GTE for two weeks before obesity induction by overfeeding. As a preventive intervention, GTE significantly decreased visceral adipose tissue accumulation in juveniles and ameliorated visceral adiposity and plasma triglyceride levels in adult zebrafish obesity models. RNA sequencing analysis was performed using liver tissues from adult obese zebrafish, with or without GTE administration, to investigate the underlying molecular mechanism. Transcriptome analysis revealed that preventive GTE treatment affects several pathways associated with anti-obesity regulation, including activation of STAT and downregulation of CEBP signaling pathways. In conclusion, GTE could be used as a preventive agent against obesity. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1420-3049 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86b9bd0cde46b3e6e9a3cc15f531eb73 https://www.mdpi.com/1420-3049/26/9/2627 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....86b9bd0cde46b3e6e9a3cc15f531eb73 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14203049 |
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