Graft Versus Host Disease After Intestinal Transplantation: A Single-center Experience
| العنوان: | Graft Versus Host Disease After Intestinal Transplantation: A Single-center Experience |
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| المؤلفون: | Elsadig Hussan, Stuart S. Kaufman, Raffaelle Girlanda, Cal S. Matsumoto, Nada Yazigi, Ekong U, K. Khan, Helena B. Pasieka, Alexander Kroemer, Shahira Ghobrial, Thomas M. Fishbein, Olga A. Timofeeva, Sukanya Subramanian, Guerra J, Jason Hawksworth |
| المصدر: | Transplantation Direct, Vol 7, Iss 8, p e731 (2021) Transplantation Direct |
| بيانات النشر: | Wolters Kluwer, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Transplantation, medicine.medical_specialty, Intestinal Transplantation, medicine.diagnostic_test, RD1-811, Donor selection, business.industry, medicine.medical_treatment, Hazard ratio, Immunosuppression, medicine.disease, Rash, Gastroenterology, Graft-versus-host disease, surgical procedures, operative, Internal medicine, Skin biopsy, ComputingMethodologies_DOCUMENTANDTEXTPROCESSING, medicine, Surgery, medicine.symptom, business, Survival analysis |
| الوصف: | Supplemental Digital Content is available in the text. Background. Graft versus host disease (GVHD) is an uncommon but highly morbid complication of intestinal transplantation (ITx). In this study, we reviewed our 17-y experience with GVHD focusing on factors predicting GVHD occurrence and survival. Methods. Retrospective review of 271 patients who received 1 or more ITx since program inception in 2003 with survival analysis using Cox proportional hazard modeling. Results. Of 271 patients, 28 developed GHVD 34 (18–66) d after ITx presenting with rash or rash with fever in 26, rectosigmoid disease in 1, and hemolysis in 1; other sites, mainly rectosigmoid colon, were involved in 13. Initial skin biopsy demonstrated classic findings in 6, compatible findings in 14, and no abnormalities in 2. Additional sites of GVHD later emerged in 14. Of the 28 patients, 16 died largely from sepsis, the only independent hazard for death (hazard ratio [HR], 37.4181; P = 0.0008). Significant (P |
| اللغة: | English |
| تدمد: | 2373-8731 |
| DOI: | 10.1097/TXD.0000000000001187 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86b49daa794338ed1067cc1b2c244cf6 http://journals.lww.com/transplantationdirect/fulltext/10.1097/TXD.0000000000001187 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....86b49daa794338ed1067cc1b2c244cf6 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 23738731 |
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| DOI: | 10.1097/TXD.0000000000001187 |