Simultaneous expression of steroid sulfatase and androgen receptor reduced overall survival of patients with epithelial ovarian tumors
| العنوان: | Simultaneous expression of steroid sulfatase and androgen receptor reduced overall survival of patients with epithelial ovarian tumors |
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| المؤلفون: | Elizabeth Rendón, Andrés Quintanar-Stephano, María J. Gómora, Horacio Noé López-Basave, Delia Pérez-Montiel, Paulina Garcia de Alba Graue, E. Pedernera, Miguel Ángel Almaraz, Flavia Morales-Vásquez, Carmen Méndez, Argelia Calvillo-Robledo |
| المصدر: | Journal of Ovarian Research Journal of Ovarian Research, Vol 14, Iss 1, Pp 1-8 (2021) |
| بيانات النشر: | BioMed Central, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0301 basic medicine, Adult, medicine.medical_treatment, Carcinoma, Ovarian Epithelial, Epithelial ovarian tumor, Asymptomatic, Steroid, 03 medical and health sciences, 0302 clinical medicine, Ovarian cancer, Steroid sulfatase, medicine, Humans, Receptor, Testosterone, business.industry, Research, Obstetrics and Gynecology, Gynecology and obstetrics, Middle Aged, medicine.disease, Survival Analysis, Androgen receptor, 030104 developmental biology, Oncology, Receptors, Androgen, 030220 oncology & carcinogenesis, RG1-991, Cancer research, Androgens, Female, Steryl-Sulfatase, medicine.symptom, business, Hormone |
| الوصف: | Background Ovarian cancer is usually diagnosed at an advanced stage due to its early asymptomatic course and late-stage non-specific symptoms. This highlights the importance of researching the molecular mechanisms involved in ovarian carcinogenesis as well as the discovery of novel prognostic markers that could help improve the survival outcome of patients. The aim of this study was to evaluate the expression of the steroid sulfatase (STS) in 154 samples of primary ovarian tumors. This protein is crucial in the intracellular conversion of sulfated steroid hormones to active steroid hormones. The presence of STS, 3β-HSD, and 17β-HSD1 result in the production of testosterone which act through the androgen receptor (AR) in the tumor cell. The presence of STS and AR in epithelial ovarian tumors and their association to the overall survival of patients was evaluated using Kaplan–Meier and Cox regression analyses. Results Immunoreactivity for STS was detected in 65% of the tumors and no association was observed with histological subtypes and clinical stages of the tumor. The STS expression in the tumors exhibiting immunoreactive AR resulted in a reduced survival (log-rank test, p = 0.032) and a risk factor in univariate and multivariate analysis, HR = 3.46, CI95% 1.00–11.92, p = 0.049 and HR = 5.92, CI95% 1.34–26.09, p = 0.019, respectively. Conclusions These findings suggest that the intracellular synthesis of testosterone acting through its receptor can promote tumor growth and progression. Moreover, the simultaneous expression of STS and AR constitutes an independent predictor of poor prognosis in epithelial ovarian tumors. |
| اللغة: | English |
| تدمد: | 1757-2215 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::862e1fd6eccbbf81efa6f3c4ba42c258 http://europepmc.org/articles/PMC8320173 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....862e1fd6eccbbf81efa6f3c4ba42c258 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17572215 |
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