A comprehensive overview of the existing microbial symbionts in mosquito vectors: An important tool for impairing pathogen transmission

التفاصيل البيبلوغرافية
العنوان: A comprehensive overview of the existing microbial symbionts in mosquito vectors: An important tool for impairing pathogen transmission
المؤلفون: Vandana Vandana, Madhavinadha Prasad Kona, Jatin Kumar, Om P. Singh, Kailash C. Pandey
المصدر: Experimental parasitology. 243
سنة النشر: 2022
مصطلحات موضوعية: Insecticides, Infectious Diseases, Bacteria, RNA, Ribosomal, 16S, Immunology, Anopheles, Animals, Humans, Parasitology, General Medicine, Mosquito Vectors, Malaria
الوصف: The emergence of drug-resistant parasites and/or insecticide-resistant mosquito vectors necessitates developing alternative tools that either supplement or replace the conventional malaria control strategies. Trans-infecting the mosquito vector with symbionts that can either compete with a targeted pathogen or manipulate the host biology by reducing its vectorial capacity could be a promising and innovative biological approach for the control of infectious diseases This idea could be utilized to develop a novel and efficient vector control strategy; symbionts are dispersed into vector populations to reduce their ability to transmit human pathogens. Here, we reported the natural existence of Microsporidian (an obligate fungus) in the field-collected An. stephensi mosquito. However, laboratory-reared An. stephensi and An. culicifacies did not exhibit microsporidian infection. Similarly, 16s rRNA PCR identified ∼1kb amplicons in laboratory-reared An. stephensi and An. culicifacies, indicating the presence of naturally residing different bacterial species. DNA sequencing of these amplicons revealed the identities of different bacteria which are not well-characterized in terms of plasmodia-interaction activity in the Indian malaria vector. This article summarizes an overview of the previously studied microbial symbionts for their role in Plasmodium transmission along with a list of new or unexplored symbionts in the disease transmitting mosquito vectors. The summarized information could be utilized to explore such microbial symbionts for their role in Plasmodium-transmission biology in-depth and implementation in the malaria control interventions globally.
تدمد: 1090-2449
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8607a90b8044debb97b3379c479e9e9f
https://pubmed.ncbi.nlm.nih.gov/36349579
Rights: CLOSED
رقم الانضمام: edsair.doi.dedup.....8607a90b8044debb97b3379c479e9e9f
قاعدة البيانات: OpenAIRE