Circulating Undercarboxylated Osteocalcin as Estimator of Cardiovascular and Type 2 Diabetes Risk in Metabolic Syndrome Patients
| العنوان: | Circulating Undercarboxylated Osteocalcin as Estimator of Cardiovascular and Type 2 Diabetes Risk in Metabolic Syndrome Patients |
|---|---|
| المؤلفون: | Beatriz García-Fontana, Enrique García-Recio, Naomi Cano-Ibáñez, Blanca Riquelme-Gallego, Cristina García-Fontana, Francisco Andújar-Vera, Laura García-Molina, Guillermo Sanchez-Delgado, Sheila González-Salvatierra, Virginia Martínez-Ruiz, Aurora Bueno-Cavanillas, Manuel Muñoz-Torres |
| المساهمون: | [Riquelme-Gallego,B, García-Molina,L, Cano-Ibáñez,N, Martínez-Ruiz,V, Bueno-Cavanillas,A] Department of Preventive Medicine and Public Health, University of Granada, Granada, Spain. [Riquelme-Gallego,B, Andújar-Vera,F, García-Fontana,C, González-Salvatierra,S] Fundación para la Investigación Biosanitaria de Andalucía Oriental (FIBAO), Granada, Spain. [Riquelme-Gallego,B, González-Salvatierra,S, Bueno-Cavanillas,A, Muñoz-Torres,M, García-Fontana,B] Instituto de Investigación Biosanitaria de Granada (ibs.GRANADA), Granada, Spain. [Riquelme-Gallego,B, Bueno-Cavanillas,A] CIBER of Epidemiology and Public Health (CIBERESP), Carlos III Institute of Health, Madrid, Spain. [Sánchez-Delgado,G] PROFITH 'PROmotingFITness and Health through physical activity' Research Group, Department of Physical Education and Sport, Faculty of Sport Sciences, University of Granada, Granada, Spain. [González-Salvatierra,S, Muñoz-Torres,M] Department of Medicine, Faculty of Medicine, University of Granada, Granada, Spain. [García-Recio,E] Nursing Department, Faculty of Health Sciences, University of Granada, Granada, Spain. [Muñoz-Torres,M, García-Fontana,B] Bone Metabolic Unit, Endocrinology and Nutrition Division, San Cecilio University Hospital, Granada, Spain. [Muñoz-Torres,M, García-Fontana,B] CIBER of Fragility and Healthy Aging (CIBERFES), Carlos III Institute of Health, Madrid, Spain., Tis work was supported by Junta de Andalucía grant (PI-0207-2016, 2016) and Instituto de Salud-Carlos III grants (PI18- 00803, 2018, PI18-01235, 2018) co-funded by the European Regional Development Fund (FEDER). |
| المصدر: | Digibug. Repositorio Institucional de la Universidad de Granada instname Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020) Scientific Reports Digibug: Repositorio Institucional de la Universidad de Granada Universidad de Granada (UGR) |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Síndrome metabólico, Male, endocrine system diseases, lcsh:Medicine, Type 2 diabetes, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Probability::Risk::Risk Factors [Medical Subject Headings], Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings], Endocrinology, 0302 clinical medicine, Diabetes mellitus, Risk Factors, 030212 general & internal medicine, lcsh:Science, Persons::Persons::Age Groups::Adult::Aged [Medical Subject Headings], Metabolic Syndrome, education.field_of_study, Multidisciplinary, Area under the curve, Middle Aged, Cardiovascular Diseases, Biomarker (medicine), Female, Enfermedades cardiovasculares, Risk assessment, Factores de riesgo, medicine.medical_specialty, Population, Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Carrier Proteins::Calcium-Binding Proteins::Osteocalcin [Medical Subject Headings], Osteocalcin, Check Tags::Male [Medical Subject Headings], 030209 endocrinology & metabolism, Risk Assessment, Article, 03 medical and health sciences, Internal medicine, medicine, Humans, education, Diseases::Cardiovascular Diseases [Medical Subject Headings], Aged, Receiver operating characteristic, Diseases::Nutritional and Metabolic Diseases::Metabolic Diseases::Metabolic Syndrome X [Medical Subject Headings], business.industry, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Models, Theoretical::Models, Statistical::Linear Models [Medical Subject Headings], Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Probability::Risk::Risk Assessment [Medical Subject Headings], lcsh:R, Diseases::Endocrine System Diseases::Diabetes Mellitus::Diabetes Mellitus, Type 2 [Medical Subject Headings], Persons::Persons::Age Groups::Adult::Middle Aged [Medical Subject Headings], medicine.disease, Osteocalcina, Biomarcadores, Risk factors, Check Tags::Female [Medical Subject Headings], Diabetes Mellitus, Type 2, Linear Models, lcsh:Q, Metabolic syndrome, business, Biomarkers |
| الوصف: | Undercarboxylated osteocalcin (ucOC) could be a biomarker of glucose disturbances and cardiovascular risk. Our study aimed to determine the association between serum levels of ucOC and cardiovascular risk in metabolic syndrome (MetS) patients and to analyse its potential role as estimator of type 2 diabetes (T2D) risk in this population. This cross-sectional study included 235 patients with MetS, 53.2% women, aged 55–75 years. Circulating ucOC levels were measured by ELISA. Cardiovascular risk was determined as Z-score of the diagnostic criteria for MetS (CV-ZS). Linear regression model was performed to analyse the association between circulating ucOC and CV-ZS. A receiver operating curve (ROC) was performed to analyse the usefulness of ucOC as T2D risk estimator. Patients above the CV-ZS median showed signifcant lower ucOC levels. We found an inverse association between ucOC levels and CV-ZS in MetS patients without T2D. Patients with ucOC levels below the 25th percentile showed worse cardiometabolic profle and higher cardiovascular and T2D risk. The area under the curve performed better when ucOC levels were included along with the classic T2D risk factors. The measurement of circulating ucOC could be a useful tool to identify increased cardiovascular and T2D risk in MetS patients without T2D. Junta de Andalucia PI-0207-2016 European Union (EU) PI18-00803 PI18-01235 |
| وصف الملف: | application/pdf |
| اللغة: | English |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85d542e500205e7c4be68f7592d27628 https://www.nature.com/articles/s41598-020-58760-7.pdf |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....85d542e500205e7c4be68f7592d27628 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |