A young girl with severe polyarteritis nodosa successfully treated with tocilizumab: a case report
| العنوان: | A young girl with severe polyarteritis nodosa successfully treated with tocilizumab: a case report |
|---|---|
| المؤلفون: | Florence Aeschlimann, Margaux Boistault, Pierre Quartier, Mireia Lopez Corbeto, Ariadna Carsi Durall, Laura Berbel Arcobé |
| المساهمون: | Institut Català de la Salut, [Boistault M, Aeschlimann FA] Department of Pediatric Immunology-Hematology and Rheumatology, Necker University Hospital – Assitance Publique-Hopitaux de Paris, Paris, France. [Lopez Corbeto M] Unitat de Reumatologia Pediàtrica, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Quartier P] Department of Pediatric Immunology-Hematology and Rheumatology, Necker University Hospital – Assitance Publique-Hopitaux de Paris, Paris, France. Université de Paris, Imagine Institute, Paris, France. [Berbel Arcobé L] Rheumatology Department, Mútua de Terrassa University Hospital, Terrassa, Spain. [Carsi Durall A] Unitat d’Urgències Pediàtriques, Vall d’Hebron Hospital Universitari, Barcelona, Spain, Vall d'Hebron Barcelona Hospital Campus |
| المصدر: | Scientia Pediatric Rheumatology Online Journal Pediatric Rheumatology Online Journal, Vol 19, Iss 1, Pp 1-6 (2021) |
| بيانات النشر: | BMC, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | musculoskeletal diseases, medicine.medical_specialty, Cyclophosphamide, Otros calificadores::Otros calificadores::/farmacoterapia [Otros calificadores], Azathioprine, Case Report, Diseases of the musculoskeletal system, Persons::Age Groups::Child::Child, Preschool [NAMED GROUPS], Antibodies, Monoclonal, Humanized, Other subheadings::Other subheadings::/drug therapy [Other subheadings], Amino Acids, Peptides, and Proteins::Proteins::Blood Proteins::Immunoproteins::Immunoglobulins::Antibodies::Antibodies, Monoclonal::Antibodies, Monoclonal, Humanized [CHEMICALS AND DRUGS], Gastroenterology, Pediatrics, RJ1-570, chemistry.chemical_compound, Tocilizumab, Rheumatology, Refractory, Prednisone, Internal medicine, medicine, Immunology and Allergy, Humans, aminoácidos, péptidos y proteínas::proteínas::proteínas sanguíneas::inmunoproteínas::inmunoglobulinas::anticuerpos::anticuerpos monoclonales::anticuerpos monoclonales humanizados [COMPUESTOS QUÍMICOS Y DROGAS], Child, skin and connective tissue diseases, Vasculitis - Tractament, Cardiovascular Diseases::Vascular Diseases::Vasculitis::Arteritis::Polyarteritis Nodosa [DISEASES], Anticossos monoclonals - Ús terapèutic, business.industry, Polyarteritis nodosa, Foot, Standard treatment, personas::Grupos de Edad::niño::niño preescolar [DENOMINACIONES DE GRUPOS], medicine.disease, Hand, enfermedades cardiovasculares::enfermedades vasculares::vasculitis::arteritis::poliarteritis nudosa [ENFERMEDADES], chemistry, RC925-935, Child, Preschool, Pediatrics, Perinatology and Child Health, Female, business, Infants, medicine.drug, Systemic vasculitis |
| الوصف: | Background Childhood Polyarteritis nodosa (PAN) is a systemic vasculitis with necrotizing inflammation of medium- and small-sized arteries. Disease evolution may be severe and refractory to standard treatment including prednisone, azathioprine and cyclophosphamide. Case presentation We present the case of a young girl with severe PAN resulting in progressive ischemia and necrosis of fingers and toes. Biological work-up revealed increased acute phase reactants and interleukin-6 levels. She was only partially controlled despite high-dose corticosteroids and cyclophosphamide infusions, and eventually achieved rapid improvement and sustained remission on tocilizumab. Further, we review the current evidence of the interleukin-6-inhibitor tocilizumab for the treatment of PAN. Conclusion Tocilizumab may be an efficient therapeutic option in a subset of treatment-refractory children with PAN. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85cbb96e620dc93a9791adc9b8c1cda2 https://hdl.handle.net/11351/7572 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....85cbb96e620dc93a9791adc9b8c1cda2 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |