Regional cerebral glucose metabolism in epilepsies with continuous spikes and waves during sleep
| العنوان: | Regional cerebral glucose metabolism in epilepsies with continuous spikes and waves during sleep |
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| المؤلفون: | Catherine Wetzburger, Nathalie Poznanski, Isabelle Jambaqué, X. De Tiège, C Chiron, Edouard Hirsch, Serge Goldman, Philippe Paquier, Olivier Dulac, Steve Laureys, Denis Verheulpen, P. Van Bogaert, D. Chaigne |
| المساهمون: | Centre for Linguistics, Vrije Universiteit Brussel |
| المصدر: | Neurology, 63 (5 Neurology Vrije Universiteit Brussel Scopus-Elsevier ResearcherID |
| سنة النشر: | 2004 |
| مصطلحات موضوعية: | Male, Central nervous system, Posterior parietal cortex, Electroencephalography, Frontal Lobe -- radionuclide imaging, Statistical parametric mapping, Epilepsy, Epilepsy -- physiopathology, Epilepsy -- radionuclide imaging, Fluorodeoxyglucose F18, Fluorodeoxyglucose F18 -- diagnostic use, medicine, Brain -- metabolism, Humans, Ictal, Child, Epilepsy -- metabolism, Sleep Disorders, Intrinsic -- physiopathology, Frontal Lobe -- physiopathology, Retrospective Studies, medicine.diagnostic_test, Brain, Sciences bio-médicales et agricoles, Glucose -- metabolism, Radiopharmaceuticals -- diagnostic use, medicine.disease, Frontal Lobe, Sleep Disorders, Intrinsic, Sleep Disorders, Intrinsic -- metabolism, medicine.anatomical_structure, Glucose, Frontal lobe, Organ Specificity, Child, Preschool, Positron-Emission Tomography, Frontal Lobe -- metabolism, Hypermetabolism, Female, Neurology (clinical), Radiopharmaceuticals, Sleep Disorders, Intrinsic -- radionuclide imaging, Psychology, Neuroscience, Brain -- radionuclide imaging |
| الوصف: | BACKGROUND: Epileptic syndromes with continuous spikes and waves during sleep (CSWS) represent a wide spectrum of epileptic conditions associated with cognitive dysfunctions that have the EEG pattern of CSWS as a common feature. Reported are the results of voxel-based analyses of brain glucose metabolism performed in a group of 18 children with CSWS. METHODS: Voxel-based analyses of cerebral glucose metabolism were performed using statistical parametric mapping (SPM). First, each patient was compared with a control group and the influence of age, epileptic activity, and corticosteroid treatment on metabolic abnormalities was studied. Also, disease-related changes in the contribution of a brain area to the level of metabolic activity in another brain area were investigated using pathophysiologic interactions in groups of patients compared with the control group. RESULTS: Individual SPM analyses identified three metabolic patterns: association of hypermetabolic and hypometabolic areas, hypometabolic areas only, and normal pattern. Age and intensity of awake interictal spiking did not significantly differ in patients showing focal hypermetabolism compared with the other ones. Treatment with corticosteroids was associated with absence of focal hypermetabolism. In the group of patients with hypermetabolic areas, analyses of pathophysiologic interactions showed disease-related altered functional connectivity between the parietal and frontal cortices. CONCLUSIONS: Cerebral metabolic patterns are heterogeneous among patients with CSWS. This metabolic heterogeneity could be related to the use of corticosteroid treatment before PET. The parietofrontal altered connectivity observed in patients with hypermetabolism is interpreted as a phenomenon of remote inhibition of the frontal lobes induced by highly epileptogenic and hypermetabolic posterior cortex. Journal Article Research Support, Non-U.S. Gov't info:eu-repo/semantics/published |
| وصف الملف: | 1 full-text file(s): application/pdf |
| اللغة: | English |
| تدمد: | 0028-3878 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85a8d809ac78a4896579d0054a670c84 http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/51472 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....85a8d809ac78a4896579d0054a670c84 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 00283878 |
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