Mouth occlusion pressure at 100ms (P0.1) as a respiratory biomarker in amyotrophic lateral sclerosis
| العنوان: | Mouth occlusion pressure at 100ms (P0.1) as a respiratory biomarker in amyotrophic lateral sclerosis |
|---|---|
| المؤلفون: | Mamede de Carvalho, Susana Pinto, Michael Swash |
| المساهمون: | Repositório da Universidade de Lisboa |
| المصدر: | Repositório Científico de Acesso Aberto de Portugal Repositório Científico de Acesso Aberto de Portugal (RCAAP) instacron:RCAAP |
| بيانات النشر: | Informa UK, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Male, Phrenic nerve conduction, medicine.medical_specialty, Vital Capacity, education, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Humans, Respiratory muscle weakness, Medicine, Occlusion pressure, Respiratory function, Respiratory system, Amyotrophic lateral sclerosis, health care economics and organizations, Aged, Mouth, Progression, business.industry, Respiratory center, social sciences, medicine.disease, Respiratory Muscles, humanities, Phrenic Nerve, Mouth occlusion pressure, Neurology, nervous system, Cardiology, Biomarker (medicine), Female, Neurology (clinical), Airway, business, Biomarkers, 030217 neurology & neurosurgery |
| الوصف: | Copyright © 2020 World Federation of Neurology on behalf of the Research Group on Motor Neuron Diseases Airway pressure in the first 100ms of an occluded inspiration (P0.1) evaluates the respiratory center activity, increasing in the presence of respiratory muscle weakness. It is uncertain if its activity can compensate for respiratory muscles weakness in amyotrophic lateral sclerosis (ALS). Methods: Consecutive ALS patients with P0.1 evaluated at first visit were included. Depending on P0.1 percentile, patients were divided in three groups: G1 (90th percentile). Body mass index (BMI), functional ALS rating scale and its subscores, respiratory function tests, including forced vital capacity, maximal inspiratory (MIP) and expiratory pressures, percentage of P0.1 (%P0.1), blood gas analyses, phrenic nerve motor amplitude (MeanPhrenAmpl) were compared. P0.1/MIP and %P0.1 predictors were explored by linear and multinomial logistic regression analyses. p 147.12, P0.1/MIP = 7.92 ± 4.62) predominantly included older patients (p = 0.033), women (p = 0.012), with lower MeanPhrenAmpl (p = 0.039). Discussion: ALS patients with respiratory failure can show high or low P01 values, related to phenotype. Possible central drive reactivity and exhaustion, and the role of respiratory-metabolic-renal buffering system should be further addressed. This work was partially funded by the project: Comprehensive evaluation of circulating MicroRNA as diagnostic and prognostic biomarkers in Amyotrophic Lateral Sclerosis (PTDC/MEC-NEU/31195/2017). |
| وصف الملف: | application/pdf |
| اللغة: | English |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::848f398e5e66fd4186c4afafd2a150b6 https://hdl.handle.net/10451/48335 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....848f398e5e66fd4186c4afafd2a150b6 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |