التفاصيل البيبلوغرافية
| العنوان: |
Platelet-Monocyte Aggregates and C-Reactive Protein are Associated with VTE in Older Surgical Patients |
| المؤلفون: |
Matthew T. Rondina, Robert C. Pendleton, Christopher L. Peters, Larry W. Kraiss, David L. Kaplan, Mark A. Supiano, Guy A. Zimmerman, Lauren Shih, T. Charles Casper, Andrew S. Weyrich |
| المصدر: |
Scientific Reports |
| بيانات النشر: |
Nature Publishing Group, 2016. |
| سنة النشر: |
2016 |
| مصطلحات موضوعية: |
0301 basic medicine, Blood Platelets, medicine.medical_specialty, Integrin, 030204 cardiovascular system & hematology, Gastroenterology, Monocytes, Article, Proinflammatory cytokine, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Internal medicine, Medicine, Humans, Platelet, Platelet activation, cardiovascular diseases, Aged, Multidisciplinary, biology, business.industry, Monocyte, C-reactive protein, Venous Thromboembolism, Middle Aged, equipment and supplies, Surgery, 030104 developmental biology, medicine.anatomical_structure, C-Reactive Protein, Surgical Procedures, Operative, biology.protein, Female, business, Venous thromboembolism, Surgical patients |
| الوصف: |
Emerging evidence implicates platelets as key mediators of venous thromboembolism (VTE). Nevertheless, the pathways by which platelets and circulating procoagulant proteins synergistically orchestrate VTE remain incompletely understood. We prospectively determined whether activated platelets and systemic procoagulant factors were associated with VTE in 32 older orthopedic surgery patients. Circulating platelet-monocyte aggregates (PMAs), p-selectin expression (P-SEL), and integrin αIIbβ3 activation (PAC-1 binding) were assessed pre-operatively and 24 hours post-operatively. The proinflammatory and procoagulant molecule C-reactive protein (CRP), which induces PMA formation in vitro, along with plasma d-dimer and fibrinogen levels were also measured. The primary outcome was VTE occurring within 30 days post-operatively. Overall, 40.6% of patients developed VTE. Patients with VTE had a significant increase in circulating PMAs and CRP post-operatively, compared to those without VTE. Changes in PMA and CRP in VTE patients were significantly correlated (r2 = 0.536, p = 0.004). In contrast, P-SEL expression and PAC-1 binding, fibrinogen levels, and d-dimers were not associated with VTE. This is the first study to identify that increased circulating PMAs and CRP levels are early markers associated with post-surgical VTE. Our findings also provide new clinical evidence supporting the interplay between PMAs and CRP in patients with VTE. |
| اللغة: |
English |
| تدمد: |
2045-2322 |
| DOI: |
10.1038/srep27478 |
| URL الوصول: |
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82f3010d773d63e7bb6935113a25bbb4 |
| Rights: |
OPEN |
| رقم الانضمام: |
edsair.doi.dedup.....82f3010d773d63e7bb6935113a25bbb4 |
| قاعدة البيانات: |
OpenAIRE |