Antiplatelet Effect of Ketorolac in Children After Congenital Cardiac Surgery
| العنوان: | Antiplatelet Effect of Ketorolac in Children After Congenital Cardiac Surgery |
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| المؤلفون: | John S. Kim, Jon Kaufman, Sonali S. Patel, Eduardo da Cruz, Marilyn J. Manco-Johnson, Jorge Di Paola |
| المصدر: | World Journal for Pediatric and Congenital Heart Surgery. 9:651-658 |
| بيانات النشر: | SAGE Publications, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Heart Defects, Congenital, Male, medicine.medical_specialty, Adolescent, Platelet Aggregation, 030204 cardiovascular system & hematology, Platelet inhibition, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, 030202 anesthesiology, Internal medicine, Humans, Medicine, Platelet, Postoperative Period, Prospective Studies, Cardiac Surgical Procedures, Child, Inhibitory effect, Hematology, business.industry, Anti-Inflammatory Agents, Non-Steroidal, Infant, Newborn, Infant, Thrombosis, General Medicine, Thrombelastography, Cardiac surgery, body regions, Ketorolac, chemistry, Child, Preschool, Anesthesia, Pediatrics, Perinatology and Child Health, Coagulation anticoagulation, Female, Surgery, Arachidonic acid, Cardiology and Cardiovascular Medicine, business, medicine.drug |
| الوصف: | Background: Ketorolac is used for pediatric analgesia after surgery despite its known platelet inhibition via the arachidonic acid (AA) pathway. The degree of platelet inhibitory effect after cardiac surgery is not well characterized. Thromboelastography with platelet mapping (TEG-PM) is emerging as a frequently used test to evaluate platelet inhibition via the AA pathway. Methods: Post hoc analysis of a data set collected in a prospective observational cohort study evaluating platelet inhibition in children after congenital heart surgery with cardiopulmonary bypass (CPB). Categorization into two groups: (1) received ketorolac and (2) did not receive ketorolac for analgesia after surgery. The TEG-PM was evaluated at two time points (prior to surgery and 12-48 hours after CPB). Results: Fifty-three children were studied; mean age was 6.6 (range: 0.07-16.7) years and 45% (n = 24) were female. Participants were distributed into two groups by ketorolac use, 41 within the ketorolac group and 12 in the no ketorolac group. All 41 participants who received ketorolac had platelet inhibition and 11 (91.7%) of 12 participants who did not receive ketorolac had normal platelet function after surgery ( P < .0001). There was no difference in patient characteristics or clinical data between the two groups. Conclusions: Ketorolac use in a cohort of children after congenital cardiac surgery was associated with platelet inhibition via the AA pathway when evaluated by TEG-PM. |
| تدمد: | 2150-136X 2150-1351 |
| DOI: | 10.1177/2150135118799041 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::826c14a6c5c422feb0aae1883c51fdb2 https://doi.org/10.1177/2150135118799041 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....826c14a6c5c422feb0aae1883c51fdb2 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 2150136X 21501351 |
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| DOI: | 10.1177/2150135118799041 |