Deep sequencing reveals persistence of cell-associated mumps vaccine virus in chronic encephalitis
| العنوان: | Deep sequencing reveals persistence of cell-associated mumps vaccine virus in chronic encephalitis |
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| المؤلفون: | Christopher Ruis, Waseem Qasim, Judith Breuer, Julianne R Brown, Stephen McQuaid, Sarah M. Connaughton, Sofia Morfopoulou, Kimberly Gilmour, W. Paul Duprex, Deborah Ferguson, Edward T. Mee, Alex Virasami, Marios Kaliakatsos, W. K. Kling Chong, Simon M. L. Paine, Thomas S. Jacques, Vincent Plagnol, J. Ciaran Hutchinson, Hong Zhan, Mike Hubank, Silke Schepelmann |
| المصدر: | Acta Neuropathologica |
| بيانات النشر: | Springer Science and Business Media LLC, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | 0301 basic medicine, Jeryl Lynn, Male, Biopsy, Clinical Neurology, Mumps Vaccine, Case Report, Mumps virus, medicine.disease_cause, Rubella, Measles, Pathology and Forensic Medicine, 03 medical and health sciences, Cellular and Molecular Neuroscience, 0302 clinical medicine, Fatal Outcome, Medicine, Humans, Encephalitis, Viral, Severe combined immunodeficiency, medicine.diagnostic_test, business.industry, Brain biopsy, Brain, High-Throughput Nucleotide Sequencing, Infant, medicine.disease, Virology, 3. Good health, 030104 developmental biology, Mumps vaccine, Immunology, Chronic Disease, Severe Combined Immunodeficiency, Neurology (clinical), business, 030217 neurology & neurosurgery, Encephalitis |
| الوصف: | Routine childhood vaccination against measles, mumps and rubella has virtually abolished virus-related morbidity and mortality. Notwithstanding this, we describe here devastating neurological complications associated with the detection of live-attenuated mumps virus Jeryl Lynn (MuVJL5) in the brain of a child who had undergone successful allogeneic transplantation for severe combined immunodeficiency (SCID). This is the first confirmed report of MuVJL5 associated with chronic encephalitis and highlights the need to exclude immunodeficient individuals from immunisation with live-attenuated vaccines. The diagnosis was only possible by deep sequencing of the brain biopsy. Sequence comparison of the vaccine batch to the MuVJL5 isolated from brain identified biased hypermutation, particularly in the matrix gene, similar to those found in measles from cases of SSPE. The findings provide unique insights into the pathogenesis of paramyxovirus brain infections. Electronic supplementary material The online version of this article (doi:10.1007/s00401-016-1629-y) contains supplementary material, which is available to authorized users. |
| تدمد: | 1432-0533 0001-6322 |
| DOI: | 10.1007/s00401-016-1629-y |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::824f13850c13ea000ccc18599ae2c617 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....824f13850c13ea000ccc18599ae2c617 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14320533 00016322 |
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| DOI: | 10.1007/s00401-016-1629-y |