Fungal infections in hematopoietic stem-cell transplant patients: a review of epidemiology, diagnosis, and management
| العنوان: | Fungal infections in hematopoietic stem-cell transplant patients: a review of epidemiology, diagnosis, and management |
|---|---|
| المؤلفون: | Sorabh Sharma, Jay Parekh, Vishal Jindal, Prachi Pednekar, Michael Stender, Ishmael Jaiyesimi, Mandeep Singh Rahi, Kulothungan Gunasekaran |
| المصدر: | Therapeutic Advances in Infectious Disease, Vol 8 (2021) Therapeutic Advances in Infectious Disease |
| بيانات النشر: | SAGE Publishing, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | medicine.medical_specialty, Itraconazole, Population, Lymphoproliferative disorders, Review, Infectious and parasitic diseases, RC109-216, Amphotericin B, stem cell transplant, medicine, Pharmacology (medical), Intensive care medicine, education, Adverse effect, anti-fungal, Voriconazole, education.field_of_study, business.industry, Hematopoietic stem cell, Breakthrough infection, bone marrow transplant, medicine.disease, Infectious Diseases, medicine.anatomical_structure, Infectious Disease in Hematopoietic Stem Cell Transplantation, fungal infections, business, fungal prophylaxis, medicine.drug |
| الوصف: | The advent of bone marrow transplant has opened doors to a different approach and offered a new treatment modality for various hematopoietic stem-cell-related disorders. Since the first bone marrow transplant in 1957, there has been significant progress in managing patients who undergo bone marrow transplants. Plasma-cell disorders, lymphoproliferative disorders, and myelodysplastic syndrome are the most common indications for hematopoietic stem-cell transplant. Despite the advances, invasive fungal infections remain a significant cause of morbidity and mortality in this high-risk population. The overall incidence of invasive fungal infection in patients with hematopoietic stem-cell transplant is around 4%, but the mortality in patients with allogeneic stem-cell transplant is as high as 13% in one study. Type of stem-cell transplant, conditioning regimen, and development of graft- versus-host disease are some of the risk factors that impact the risk and outcomes in patients with invasive fungal infections. Aspergillus and candida remain the two most common organisms causing invasive fungal infections. Molecular diagnostic methods have replaced some traditional methods due to their simplicity of use and rapid turnaround time. Primary prophylaxis has undoubtedly shown to improve outcomes even though breakthrough infection rates remain high. The directed treatment has seen a significant shift from amphotericin B to itraconazole, voriconazole, and echinocandins, which have shown better efficacy and fewer adverse effects. In this comprehensive review, we aim to detail epidemiology, risk factors, diagnosis, and management, including prophylaxis, empiric and directed management of invasive fungal infections in patients with hematopoietic stem-cell transplant. |
| اللغة: | English |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::823fe49eecf01cf5e45a9e1ad7e7cc9b https://doaj.org/article/f8c7acef53cb4cab9cb026a69feda6b8 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....823fe49eecf01cf5e45a9e1ad7e7cc9b |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |