Assessment of aPTT-based clot waveform analysis for the detection of haemostatic changes in different types of infections
| العنوان: | Assessment of aPTT-based clot waveform analysis for the detection of haemostatic changes in different types of infections |
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| المؤلفون: | Lawrence Cheng Kiat Ng, Gayathry Morvil, Wan Hui Wong, Lai Heng Lee, Yvonne Miao Hui Chu, Shan Shan Lim, Chuen Wen Tan, Heng Joo Ng, Dillon Guo Dong Yeo, McVin Hua Heng Cheen |
| المصدر: | Scientific Reports, Vol 10, Iss 1, Pp 1-7 (2020) Scientific Reports |
| بيانات النشر: | Springer Science and Business Media LLC, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, medicine.medical_specialty, lcsh:Medicine, Gastroenterology, Article, Procalcitonin, Dengue, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, Coagulopathy, Humans, lcsh:Science, Automated analyser, Respiratory Tract Infections, Aged, Aged, 80 and over, Disseminated intravascular coagulation, Hemostasis, Multidisciplinary, Respiratory tract infections, biology, medicine.diagnostic_test, business.industry, lcsh:R, C-reactive protein, Bacterial Infections, Disseminated Intravascular Coagulation, Middle Aged, medicine.disease, C-Reactive Protein, 030104 developmental biology, Elective Surgical Procedures, Virus Diseases, biology.protein, Infectious diseases, Female, Partial Thromboplastin Time, lcsh:Q, business, Biomarkers, 030217 neurology & neurosurgery, Partial thromboplastin time |
| الوصف: | Infections cause varying degrees of haemostatic dysfunction which can be detected by clot waveform analysis (CWA), a global haemostatic marker. CWA has been shown to predict poor outcomes in severe infections with disseminated intravascular coagulopathy. The effect of less severe bacterial and viral infections on CWA has not been established. We hypothesized that different infections influence CWA distinctively. Patients admitted with bacterial infections, dengue and upper respiratory tract viral infections were recruited if they had an activated partial thromboplastin time (aPTT) measured on admission. APTT-based CWA was performed on Sysmex CS2100i automated analyser using Dade Actin FSL reagent. CWA parameters [(maximum velocity (min1), maximum acceleration (min2) and maximum deceleration (max2)] were compared against control patients. Infected patients (n = 101) had longer aPTT than controls (n = 112) (34.37 ± 7.72 s vs 27.80 ± 1.59 s, p 2; 0.74 ± 0.16%/s2), bacterial infection has higher CWA results (6.92 ± 1.60%/s; 1.04 ± 0.28%/s2; 0.82 ± 0.24%/s2, all p 2; 0.43 ± 0.14%/s2, all p 2; 0.73 ± 0.18%/s2, all p > 0.05). CWA parameters demonstrated positive correlation with C-reactive protein levels (min1: r = 0.54, min2: r = 0.44, max2: r = 0.34; all p |
| تدمد: | 2045-2322 |
| DOI: | 10.1038/s41598-020-71063-1 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::820677cd4540fde007e59abaa29f04c1 https://doi.org/10.1038/s41598-020-71063-1 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....820677cd4540fde007e59abaa29f04c1 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20452322 |
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| DOI: | 10.1038/s41598-020-71063-1 |