Liposomal Fc Domain Conjugated to a Cancer Vaccine Enhances Both Humoral and Cellular Immunity
| العنوان: | Liposomal Fc Domain Conjugated to a Cancer Vaccine Enhances Both Humoral and Cellular Immunity |
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| المؤلفون: | Abhishek Vartak, Steven J. Sucheck, Kamal Hossain, Katherine A. Wall |
| المصدر: | ACS Omega, Vol 4, Iss 3, Pp 5204-5208 (2019) ACS Omega |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | 0303 health sciences, Cellular immunity, biology, Chemistry, General Chemical Engineering, Antigen presentation, General Chemistry, Article, 3. Good health, lcsh:Chemistry, 03 medical and health sciences, 0302 clinical medicine, Immune system, Antibody Isotype, lcsh:QD1-999, Antigen, 030220 oncology & carcinogenesis, Immunology, biology.protein, Cancer vaccine, Antibody, MUC1, 030304 developmental biology |
| الوصف: | Targeted delivery of antigens to antigen-presenting cells (APCs) by utilizing natural anticarbohydrate antibodies is a promising approach for selective uptake and enhanced antigen presentation. Previously, we reported that in the presence of a natural antibody, anti-rhamnose antibody (anti-Rha), the bacterial sugar rhamnose conjugated with liposomal cancer antigen MUC1-Tn enhances antigen presentation by APCs such as dendritic cells by targeting Fc gamma receptors. The idea was to utilize the natural human anti-Rha antibodies present in human serum for targeted delivery of cancer-specific antigens. Recently, we found that the IgG3 antibody isotype was the most prevalent anti-Rha antibody generated in mice immunized with rhamnose-Ficoll (Rha-Ficoll) antigen. In this manuscript, we have conjugated the murine IgG3-Fc with a MUC1-containing cancer vaccine and compared the humoral and cellular immune response to this vaccine with one targeted via the human anti-Rha antibody and to the MUC1 vaccine alone. This Fc approach enhanced antibody production and T-cell proliferation almost to the same level as using the anti-Rha antibody. These results suggest that targeting Fc directly to dendritic cells can be an alternative approach to human anti-Rha for generating effective antigen-primed T-cells. |
| تدمد: | 2470-1343 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8200473e4da5aba128d300384069430f https://pubmed.ncbi.nlm.nih.gov/30949616 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....8200473e4da5aba128d300384069430f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 24701343 |
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