Theranostic barcoded nanoparticles for personalized cancer medicine
| العنوان: | Theranostic barcoded nanoparticles for personalized cancer medicine |
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| المؤلفون: | Janna Shainsky Roitman, Rafi Tshuva, Ashima Kajal, Mor Goldfeder, Evgeniya Goldman, Zvi Yaari, Dov Hershkovitz, Nitsan Dahan, Dana da Silva, Efrat Barak, Avi Schroeder, Assaf Zinger |
| المصدر: | Nature Communications Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016) |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | 0301 basic medicine, Oncology, medicine.medical_specialty, Theranostic Nanomedicine, Science, Cancer therapy, Drug Evaluation, Preclinical, General Physics and Astronomy, Nanotechnology, Antineoplastic Agents, Triple Negative Breast Neoplasms, 02 engineering and technology, Kaplan-Meier Estimate, General Biochemistry, Genetics and Molecular Biology, Article, 03 medical and health sciences, Breast cancer, Cancer Medicine, Internal medicine, Cell Line, Tumor, Neoplasms, medicine, Effective treatment, Animals, Humans, Base sequence, Precision Medicine, Early Detection of Cancer, Drug Carriers, Mice, Inbred BALB C, Multidisciplinary, Base Sequence, business.industry, Cancer, General Chemistry, DNA, 021001 nanoscience & nanotechnology, Precision medicine, medicine.disease, 3. Good health, 030104 developmental biology, Nanoparticles, Female, 0210 nano-technology, business |
| الوصف: | Personalized medicine promises to revolutionize cancer therapy by matching the most effective treatment to the individual patient. Using a nanoparticle-based system, we predict the therapeutic potency of anticancer medicines in a personalized manner. We carry out the diagnostic stage through a multidrug screen performed inside the tumour, extracting drug activity information with single cell sensitivity. By using 100 nm liposomes, loaded with various cancer drugs and corresponding synthetic DNA barcodes, we find a correlation between the cell viability and the drug it was exposed to, according to the matching barcodes. Based on this screen, we devise a treatment protocol for mice bearing triple-negative breast-cancer tumours, and its results confirm the diagnostic prediction. We show that the use of nanotechnology in cancer care is effective for generating personalized treatment protocols. Determining the most effective treatment for each cancer patient is a key challenge in cancer therapy. In this article, the authors show, in a mouse model of breast cancer, that DNA barcoded nanoparticles can be used for pre-screening the efficacy of anticancer drugs. |
| تدمد: | 2041-1723 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81c44d2a4486127986a4869180ee5ca8 https://pubmed.ncbi.nlm.nih.gov/27903858 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....81c44d2a4486127986a4869180ee5ca8 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20411723 |
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