Safety Profile of Maraviroc in Patients Coinfected With HIV-1 and Hepatitis B or C Included in the Maraviroc Expanded Access Program
| العنوان: | Safety Profile of Maraviroc in Patients Coinfected With HIV-1 and Hepatitis B or C Included in the Maraviroc Expanded Access Program |
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| المؤلفون: | Jayvant Heera, Geoffrey Mukwaya, Adriano Lazzarin, Soe Than, Srinivas Rao Valluri |
| المصدر: | HIV Clinical Trials. 13:83-89 |
| بيانات النشر: | Informa UK Limited, 2012. |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Anti-HIV Agents, Etravirine, HIV Infections, medicine.disease_cause, Maraviroc, chemistry.chemical_compound, Cyclohexanes, Internal medicine, medicine, Humans, Pharmacology (medical), Darunavir, Hepatitis B virus, Coinfection, business.industry, virus diseases, Middle Aged, Triazoles, Hepatitis B, medicine.disease, Raltegravir, Hepatitis C, Virology, Infectious Diseases, chemistry, Expanded access, HIV-1, Drug Therapy, Combination, Female, Chemical and Drug Induced Liver Injury, business, medicine.drug |
| الوصف: | To evaluate the safety of maraviroc with other antiretrovirals in patients with HIV-1 coinfected with hepatitis B virus (HBV) or hepatitis C virus (HCV).This was a multicenter, noncomparative, open-label, expanded access program (EAP) initiated in February 2007. Patients with CCR5-tropic HIV-1 and HIV-1 RNA ≥ 1000 copies/mL on their current treatment received maraviroc 300 mg (150 mg with protease inhibitors) twice daily with optimized background therapy (OBT), which could include the newer agents raltegravir, etravirine, and darunavir. The adverse event (AE) profile was compared with the active and placebo arms of the maraviroc phase III clinical trials MOTIVATE 1 and 2, where the OBT did not include these agents.A total of 1,032 patients were enrolled: 51 HIV/HBV coinfected; 149 HIV/HCV coinfected, 9 HIV/HBV/HCV coinfected, and 823 HIV-1 monoinfected. Most (76%) received at least 1 newer agent. Overall AE frequency was comparable across coinfection groups (63%-72%). Hepatobiliary events were more common in HIV/HCV coinfection than in HIV monoinfection or HIV/HBV coinfection (10.0, 4.8, and 3.1 per 100 patient-years, respectively). Across all coinfection groups, there was a trend toward lower exposure-adjusted rates of serious and hepatobiliary AEs in the EAP than in the MOTIVATE studies. Grade 3/4 transaminase elevations in patients receiving maraviroc in the EAP and MOTIVATE were comparable with those seen in the MOTIVATE placebo arm.Maraviroc plus an OBT did not increase the incidence of AEs or severe laboratory liver abnormalities in HIV-1-infected patients coinfected with HBV or HCV. |
| تدمد: | 1945-5771 1528-4336 |
| DOI: | 10.1310/hct1302-83 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8155b839634c870cfe2473f917aeca15 https://doi.org/10.1310/hct1302-83 |
| رقم الانضمام: | edsair.doi.dedup.....8155b839634c870cfe2473f917aeca15 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19455771 15284336 |
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| DOI: | 10.1310/hct1302-83 |